Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants.
Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants.
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DOI：
10.1038/s41598-018-33357-3
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发表时间：
2018-10-11
影响因子：
4.6
通讯作者：
Kenny LC
中科院分区：
文献类型：
--
作者：
Togher KL;O'Keeffe GW;Khashan AS;Clarke G;Kenny LC
产前窘迫与受影响后代的不良结局有关。胎盘糖皮质激素信号的改变和随后的胎儿糖皮质激素过度分泌被认为是一种潜在的机制。婴儿性别正在成为疾病易感性的一个重要因素。本研究的目的是研究母亲在整个怀孕期间的痛苦对出生结局和胎盘糖皮质激素基因的影响，并以性别依赖的方式。参与者在整个怀孕期间完成了心理困扰问卷。通过真实的PCR分析胎盘HPD 11 B2、NR 3 C 1和FKBP 51，并测量新生儿头发中的皮质醇。孕中期应激与男性出生体重呈负相关，与女性胎盘NR3C1 mRNA呈正相关。孕中期焦虑与女性出生体重和胎盘FKBP51 mRNA呈负相关。在中介分析中，胎盘FKBP 51 mRNA表达被发现调解产前焦虑和出生体重之间的联系。新生儿皮质醇与孕中期焦虑呈负相关，与女性胎盘FKBP51 mRNA水平呈正相关。再次，FKBP51 mRNA被发现介导焦虑和新生儿皮质醇之间的联系。这些结果突出了FKBP 51在胎盘对女性产前窘迫的反应中的作用。胎盘FKBP 51在胎儿和婴儿发育中的确切作用尚未得到广泛研究，需要进一步研究。
Prenatal distress is associated with adverse outcomes in affected offspring. Alterations in placental glucocorticoid signalling and subsequent foetal overexposure to glucocorticoids have been implicated as an underlying mechanism. Infant sex is emerging as an important factor in disease susceptibility. This study aimed to examine the effects of maternal distress across pregnancy on birth outcomes and placental glucocorticoid genes in a sex-dependent manner. Participants completed psychological distress questionnaires throughout pregnancy. Placental HSD11B2, NR3C1 and FKBP51 were analysed by real time PCR and cortisol was measured in new-born hair. Second trimester stress was negatively correlated with birthweight in males and positively correlated with placental NR3C1 mRNA in females. Second trimester anxiety was negatively correlated with birthweight and placental FKBP51 mRNA in females. In mediation analysis, placental FKBP51 mRNA expression was found to mediate the link between prenatal anxiety and birthweight. New-born cortisol was negatively correlated with second trimester anxiety and positively correlated with female placental FKBP51 mRNA levels. Again, FKBP51 mRNA was found to mediate the link between anxiety and new-born cortisol. These results highlight a role for FKBP51 in the placental response to prenatal distress in females. The precise role that placental FKBP51 has in foetal and infant development has not been extensively studied and warrants further investigations.
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DOI：
10.3109/10253890.2011.623250
发表时间：
2011-11
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Buss C;Davis EP;Hobel CJ;Sandman CA
通讯作者：
Sandman CA
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
--
作者：
Grote, Nancy K.;Bridge, Jeffrey A.;Gavin, Amelia R.;Melville, Jennifer L.;Iyengar, Satish;Katon, Wayne J.
通讯作者：
Katon, Wayne J.
影响因子：
3.3
作者：
Class QA;Lichtenstein P;Långström N;D'Onofrio BM
通讯作者：
D'Onofrio BM
DOI：
10.1016/s0002-9378(88)80162-5
发表时间：
1988-10-01
影响因子：
9.8
作者：
GOLAND, RS;WARDLAW, SL;STARK, RI
通讯作者：
STARK, RI