Understanding Subset Diversity in T Cell Memory.
Understanding Subset Diversity in T Cell Memory.
复制标题
DOI：
10.1016/j.immuni.2018.02.010
复制
发表时间：
2018-02-20
期刊：
影响因子：
32.4
通讯作者：
Masopust D
中科院分区：
文献类型：
--
作者：
Jameson SC;Masopust D
近年来，在理解记忆T细胞的产生和功能方面取得了相当大的进展。在这篇综述中，我们考虑了该领域的新发展，并专注于如何新兴的差异之间的记忆细胞就其贩运，代谢，表观遗传调控和寿命可能无法适应小团体的“记忆子集”，而是个人记忆细胞的属性落在一个连续的每个这些（和其他）参数。这如何影响我们评估疫苗接种的有效性和记忆人群是否适合（或不适合）保护性免疫的方式也进行了讨论。记忆T细胞通常被解析为基于表型定义的离散子集，这些表型定义意味着在免疫中的不同作用。这篇评论认为，传统的子集命名法未能准确地涵盖在这个不同的人口功能性状的分布。
Considerable advances have been made in recent years in understanding the generation and function of memory T cells. In this review, we consider new developments in the field and focus on how emerging differences between memory cells with respect to their trafficking, metabolism, epigenetic regulation and longevity may fail to fit into small groups of “memory subsets”, but rather that the properties of individual memory cells fall on a continuum within each of these (and other) parameters. How that influences the way we assess the efficacy of vaccination and suitability (or not) of a memory population for protective immunity is also discussed. Memory T cells are typically parsed into discreet subsets based on phenotypic definitions that connote distinct roles in immunity. This review argues that the conventional subset nomenclature fails to accurately encompass the distribution of functional traits within this diverse population.
登录
查看更多内容
影响因子：
32.4
作者：
Fraser KA;Schenkel JM;Jameson SC;Vezys V;Masopust D
通讯作者：
Masopust D
影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
通讯作者：
Pearce EL
影响因子：
82.9
作者：
Gattinoni L;Lugli E;Ji Y;Pos Z;Paulos CM;Quigley MF;Almeida JR;Gostick E;Yu Z;Carpenito C;Wang E;Douek DC;Price DA;June CH;Marincola FM;Roederer M;Restifo NP
通讯作者：
Restifo NP
影响因子：
15.9
作者：
Boddupalli, Chandra Sekhar;Nair, Shiny;Dhodapkar, Madhav V.
通讯作者：
Dhodapkar, Madhav V.
影响因子：
4.4
作者：
Djenidi, Faycal;Adam, Julien;Mami-Chouaib, Fathia
通讯作者：
Mami-Chouaib, Fathia