A human memory T cell subset with stem cell-like properties.
A human memory T cell subset with stem cell-like properties.
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DOI：
10.1038/nm.2446
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发表时间：
2011-09-18
期刊：
影响因子：
82.9
通讯作者：
Restifo NP
中科院分区：
文献类型：
--
作者：
Gattinoni L;Lugli E;Ji Y;Pos Z;Paulos CM;Quigley MF;Almeida JR;Gostick E;Yu Z;Carpenito C;Wang E;Douek DC;Price DA;June CH;Marincola FM;Roederer M;Restifo NP
免疫记忆被认为取决于干细胞状的，自我更新的淋巴细胞种群，能够响应抗原重新暴露而区分效应细胞。 - 在CD45RO-，CCR7+，CD45RA+，CD62L+，CD227+，CD228+，CD228+和IL-7R-7r和IL-7r-7r-7r-7r-7r-linep和多能力的能力中+ T细胞的T细胞特征，它们表达了CD95，IL-2Rβ，CXCR3和LFA-1的水平，并暴露了与已知记忆细胞相比的许多功能属性。增殖能力增加，更有效地重构免疫缺陷宿主，并在人源性小鼠模型中介导的上抗肿瘤反应。 。
Immunological memory is thought to depend upon a stem cell-like, self-renewing population of lymphocytes capable of differentiating into effector cells in response to antigen re-exposure. Here we describe a long-lived human memory T-cell population that displays enhanced self-renewal and multipotent capacity to derive central memory, effector memory and effector T cells. These cells, specific for multiple viral and self-tumor antigens, were found within a CD45RO−, CCR7+, CD45RA+, CD62L+, CD27+, CD28+ and IL-7Rα+ T-cell compartment characteristic of naïve T cells. However, they expressed increased levels of CD95, IL-2Rβ, CXCR3, and LFA-1, and exhibited numerous functional attributes distinctive of memory cells. Compared to known memory populations, these lymphocytes displayed increased proliferative capacity, more efficiently reconstituted immunodeficient hosts and mediated superior anti-tumor responses in a humanized mouse model. The identification of a human stem cell-like memory T-cell population is of direct relevance to the design of vaccines and T-cell therapies.
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影响因子：
7
作者：
Kim PS;Ahmed R
通讯作者：
Ahmed R
影响因子：
15.3
作者：
Kimmig, Sonja;Przybylski, Grzegorz K;Schmidt, Christian A;Laurisch, Katja;Mowes, Beate;Radbruch, Andreas;Thiel, Andreas
通讯作者：
Thiel, Andreas
DOI：
10.1073/pnas.0503726102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Klebanoff, CA;Gattinoni, L;Restifo, NP
通讯作者：
Restifo, NP
影响因子：
20.3
作者：
Hinrichs, Christian S.;Borman, Zachary A.;Restifo, Nicholas P.
通讯作者：
Restifo, Nicholas P.
影响因子：
64.8
作者：
Araki, Koichi;Turner, Alexandra P.;Shaffer, Virginia Oliva;Gangappa, Shivaprakash;Keller, Susanne A.;Bachmann, Martin F.;Larsen, Christian P.;Ahmed, Rafi
通讯作者：
Ahmed, Rafi