The Transmission Route and Selection Pressure in HCV Subtype 3a and 3b Chinese Infections: Evolutionary Kinetics and Selective Force Analysis.
The Transmission Route and Selection Pressure in HCV Subtype 3a and 3b Chinese Infections: Evolutionary Kinetics and Selective Force Analysis.
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中国HCV 3a和3b亚型感染的传播途径和选择压力：进化动力学和选择力分析。
DOI：
10.3390/v14071514
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发表时间：
2022-07-11
期刊：
影响因子：
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中科院分区：
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作者：
丙型肝炎病毒（HCV）基因型3（GT-3）占所有感染的22-30%，是所有HCV基因型中第二常见的基因型。它有两个主要亚型，GT-3a和GT-3b，在传播群体中存在流行病学差异。本报告共获得56个GT-3a和64个GT-3b全基因组序列，并与来自不同国家的参考序列进行进化动力学和选择力分析。进化分析表明，HCV GT-3a可能是从印度次大陆传播到南亚、欧洲、北美，然后在中国流行的。在中国，GT-3a可能由静脉吸毒者（IDUs）传播，并在一般人群中流行，而GT-3b可能起源于IDUs，然后在献血员（BD）和IDUs之间相互传播，最终在IDUs中独立流行。此外，GT-3a和GT-3b序列在BD和IDU人群中的传播表现出不同的选择压力：IDU人群中E1和E2的阳性选择位点（PPS）比例高于BD人群。阳性选择位点数在GT-3b和IDUs中较高。这些结果表明，不同的选择性约束沿着作用于来自IDUs和BD的GT-3a和GT-3b基因组。此外，GT-3a和GT-3b在中国有不同的传播途径，这使我们能够制定针对中国的HCV预防和控制策略。
Hepatitis C virus (HCV) genotype 3 (GT-3) represents 22–30% of all infections and is the second most common genotype among all HCV genotypes. It has two main subtypes, GT-3a and GT-3b, that present epidemiological differences in transmission groups. This report generated 56 GT-3a and 64 GT-3b whole-genome sequences to conduct an evolutionary kinetics and selective force analysis with reference sequences from various countries. Evolutionary analysis showed that HCV GT-3a worldwide might have been transmitted from the Indian subcontinent to South Asia, Europe, North America and then become endemic in China. In China, GT-3a may have been transmitted by intravenous drug users (IDUs) and become endemic in the general population, while GT-3b may have originated from IDUs and then underwent mutual transmission between blood donors (BDs) and IDUs, ultimately becoming independently endemic in IDUs. Furthermore, the spread of GT-3a and GT-3b sequences from BD and IDU populations exhibit different selective pressures: the proportion of positively selected sites (PPSs) in E1 and E2 from IDUs was higher than in BDs. The number of positive selection sites was higher in GT-3b and IDUs. These results indicate that different selective constraints act along with the GT-3a and GT-3b genomes from IDUs and BDs. In addition, GT-3a and GT-3b have different transmission routes in China, which allows us to formulate specific HCV prevention and control strategies in China.
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DOI：
10.1093/infdis/jiab048
发表时间：
2022-08-26
期刊：
The Journal of infectious diseases
影响因子：
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影响因子：
5.3
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通讯作者：
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影响因子：
2
作者：
Gupte, Gouri;Ramdasi, Ashwini;Arankalle, V.
通讯作者：
Arankalle, V.
影响因子：
1.7
作者：
Bankevich, Anton;Nurk, Sergey;Pevzner, Pavel A.
通讯作者：
Pevzner, Pavel A.
DOI：
10.3390/v7092857
发表时间：
2015-09-16
期刊：
Viruses
影响因子：
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作者：
Cuypers L;Li G;Libin P;Piampongsant S;Vandamme AM;Theys K
通讯作者：
Theys K