The C-kit receptor-mediated signal transduction and tumor-related diseases.
The C-kit receptor-mediated signal transduction and tumor-related diseases.
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DOI：
10.7150/ijbs.6087
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发表时间：
2013
影响因子：
9.2
通讯作者：
Sugiyama H
中科院分区：
文献类型：
--
作者：
Liang J;Wu YL;Chen BJ;Zhang W;Tanaka Y;Sugiyama H
c-kit受体作为酪氨酸激酶家族的重要成员，通过与干细胞因子（stem cell factor， SCF）相互作用，激活下游信号分子，引起某些基因的特异性表达，调控细胞分化和增殖，抵抗细胞凋亡，在肿瘤的发生、发展、迁移和复发中发挥关键作用。SCF/c-kit信号通路异常与某些肿瘤密切相关。c-kit受体靶向药物的发现促进了临床相关癌症的诊断和治疗。本文就c-kit受体介导的信号转导及其作为肿瘤相关疾病靶点的潜在治疗应用研究进展进行综述。
As an important member of tyrosine kinase family, c-kit receptor causes specific expression of certain genes, regulates cell differentiation and proliferation, resists cell apoptosis, and plays a key role in tumor occurrence, development, migration and recurrence through activating the downstream signaling molecules following interaction with stem cell factor (SCF). The abnormality of SCF/c-kit signaling pathway is closely related to some certain tumors. The discovery of c-kit receptor-targeted drugs has promoted clinical-related cancer's diagnosis and treatment. In this paper, we review recent research progress on c-kit receptor-mediated signal transduction and its potential therapeutic application as a target in tumor-related diseases.
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影响因子：
158.5
作者：
Joensuu, H;Roberts, PJ;Demetri, GD
通讯作者：
Demetri, GD
影响因子：
11.5
作者：
Jiang, Xiaofeng;Zhou, Jun;Hodi, F. Stephen
通讯作者：
Hodi, F. Stephen
影响因子：
6.4
作者：
Ashida, Atsuko;Takata, Minoru;Saida, Toshiaki
通讯作者：
Saida, Toshiaki
影响因子：
5.7
作者：
Ikeda AK;Judelson DR;Federman N;Glaser KB;Landaw EM;Denny CT;Sakamoto KM
通讯作者：
Sakamoto KM
影响因子：
6.5
作者：
Care, RS;Valk, PJM;Reilly, JT
通讯作者：
Reilly, JT