Secondary metabolites of Alternaria: A comprehensive review of chemical diversity and pharmacological properties.
Secondary metabolites of Alternaria: A comprehensive review of chemical diversity and pharmacological properties.
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链格孢属的次生代谢物：化学多样性和药理学特性的综合综述
DOI：
10.3389/fmicb.2022.1085666
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发表时间：
2022
影响因子：
5.2
通讯作者：
Yang, Xiliang
中科院分区：
文献类型：
--
作者：
Zhao, Shiqin;Li, Juan;Liu, Jinping;Xiao, Shaoyujia;Yang, Sumei;Mei, Jiahui;Ren, Mengyao;Wu, Shuzhe;Zhang, Hongyuan;Yang, Xiliang
真菌被认为是最丰富的生物代谢物来源之一，可用于生产新型生物医学制剂。链格孢属（Alternaria），包括寄生、腐生和内生物种，是一种黑暗真菌，可以产生广泛的次生代谢物（SM），广泛分布在许多生态系统中。根据代谢物的独特结构特征，它们分为聚酮化合物、含氮化合物、醌、萜烯等。从链格孢属中提取的新天然产物具有优异的生物活性，包括抗菌、抗肿瘤、抗氧化、植物毒性和酶抑制特性。因此，链格孢属物种的生物代谢产物对于制药、工业、生物技术和医学应用具有重要意义。为了更新链格孢属真菌合成的次生代谢物目录，总结了从链格孢属真菌中分离出的 216 种新描述的代谢物，及其不同的化学结构、药理活性和可能的生物合成途径。此外，还讨论了链格孢属未来研究和开发的可能见解、途径和挑战。
Fungi are considered to be one of the wealthiest sources of bio-metabolites that can be employed for yielding novel biomedical agents. Alternaria, including parasitic, saprophytic, and endophytic species, is a kind of dark fungi that can produce a broad array of secondary metabolites (SMs) widely distributed in many ecosystems. These are categorized into polyketides, nitrogen-containing compounds, quinones, terpenes, and others based on the unique structural features of the metabolites. New natural products derived from Alternaria exhibit excellent bioactivities characterized by antibacterial, antitumor, antioxidative, phytotoxic, and enzyme inhibitory properties. Thus, the bio-metabolites of Alternaria species are significantly meaningful for pharmaceutical, industrial, biotechnological, and medicinal applications. To update the catalog of secondary metabolites synthesized by Alternaria fungi, 216 newly described metabolites isolated from Alternaria fungi were summarized with their diverse chemical structures, pharmacological activity, and possible biosynthetic pathway. In addition, possible insights, avenues, and challenges for future research and development of Alternaria are discussed.
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影响因子：
5.4
作者：
Ding H;Zhang D;Zhou B;Ma Z
通讯作者：
Ma Z
DOI：
10.3390/jof8050504
发表时间：
2022-05-12
期刊：
Journal of fungi (Basel, Switzerland)
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.7
作者：
Chatterjee, Sohini;Ghosh, Ranjan;Mandal, Narayan Chandra
通讯作者：
Mandal, Narayan Chandra
影响因子：
5.1
作者：
Li, Fengli;Ye, Zi;Zhang, Yonghui
通讯作者：
Zhang, Yonghui
影响因子：
4.6
作者：
Lee, Changyeol;Li, Wei;Shim, Sang Hee
通讯作者：
Shim, Sang Hee