Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
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作者：
二十多年的深入研究使人们对丙型肝炎病毒（HCV）有了详细的了解，丙型肝炎病毒慢性感染世界人口的2%。这一努力为开发抗病毒化合物铺平了道路，使患者免于危及生命的肝病。随着最近两种病毒蛋白酶抑制剂与聚乙二醇化干扰素-α和利巴韦林联合使用的批准，HCV治疗迎来了一个令人兴奋的新时代；然而，这仅仅是个开始。具有不同靶点的多种抗病毒药物有望实现高效的联合治疗，而治疗时间短、副作用少的无干扰素方案是HCV治疗的未来。正在进行的和未来的试验将确定最佳的抗病毒药物组合，以及当前看似丰富的药物管线是否足以成功治疗所有面临重大挑战的患者，如HCV多样性、病毒耐药性、宿主遗传的影响、晚期肝病和其他合并症。
More than two decades of intense research has provided a detailed understanding of hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has paved the way for the development of antiviral compounds to spare patients from life-threatening liver disease. An exciting new era in HCV therapy dawned with the recent approval of two viral protease inhibitors, used in combination with pegylated interferon-α and ribavirin; however, this is just the beginning. Multiple classes of antivirals with distinct targets promise highly efficient combinations, and interferon-free regimens with short treatment duration and fewer side effects are the future of HCV therapy. Ongoing and future trials will determine the best antiviral combinations and whether the current seemingly rich pipeline is sufficient for successful treatment of all patients in the face of major challenges, such as HCV diversity, viral resistance, the influence of host genetics, advanced liver disease and other co-morbidities.
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影响因子：
46.9
作者：
Einav, Shirit;Gerber, Doron;Bryson, Paul D.;Sklan, Ella H.;Elazar, Menashe;Maerkl, Sebastian J.;Glenn, Jeffrey S.;Quake, Stephen R.
通讯作者：
Quake, Stephen R.
线粒体转录和RNA聚合酶II依赖性核转录对抗病毒核糖核苷的敏感性。
影响因子：
6.7
作者：
Arnold JJ;Sharma SD;Feng JY;Ray AS;Smidansky ED;Kireeva ML;Cho A;Perry J;Vela JE;Park Y;Xu Y;Tian Y;Babusis D;Barauskus O;Peterson BR;Gnatt A;Kashlev M;Zhong W;Cameron CE
通讯作者：
Cameron CE
影响因子：
64.8
作者：
Dorner, Marcus;Horwitz, Joshua A.;Robbins, Justin B.;Barry, Walter T.;Feng, Qian;Mu, Kathy;Jones, Christopher T.;Schoggins, John W.;Catanese, Maria Teresa;Burton, Dennis R.;Law, Mansun;Rice, Charles M.;Ploss, Alexander
通讯作者：
Ploss, Alexander
DOI：
10.1073/pnas.0915117107
发表时间：
2010-02-23
影响因子：
11.1
作者：
Chockalingam, Karuppiah;Simeon, Rudo L.;Chen, Zhilei
通讯作者：
Chen, Zhilei
影响因子：
6.7
作者：
Counihan NA;Rawlinson SM;Lindenbach BD
通讯作者：
Lindenbach BD