Peptidergic modulation of neuronal circuitry controlling feeding in Aplysia
Peptidergic modulation of neuronal circuitry controlling feeding in Aplysia
复制标题
控制海兔进食的神经元回路的肽能调节
DOI：
10.1523/jneurosci.07-03-00671.1987
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
R. Scheller
中科院分区：
文献类型：
--
作者：
W. Sossin;M. Kirk;R. Scheller
我们研究了3种神经肽和生物活性胺5-羟色胺对加利福尼亚海茉莉参与摄食行为控制的运动神经元（B15和B16）和中间神经元（B4、B5）的影响。产蛋激素（ELH）、小心脏活性肽b （SCPb）和5-HT的应用在神经元中引发了突触诱导的不同模式的破裂，而PheMetArgPheamide （FMRFamide）由于突触活性而抑制放电。在B15和B16中记录的重复ipsp是由5-HT和SCPb诱导的，并被FMRFamide抑制。这些物质也可能直接起作用：在阻断突触传递的溶液中，SCPb能激发B15， ELH能激发B16, 5-HT能激发B15、B16和B4， FMRFamide能抑制B15和B16并激发B4。我们认为，颊神经节中枢模式发生器的输出可能被这些候选递质调制以产生不同的运动神经元活动模式。我们还注意到两个运动神经元内在特性的差异。B15具有SCPb免疫反应性，而B16不具有。这一发现表明B15可能是先前在ARC肌中发现的SCPb免疫反应性的来源，并且SCPb可能以自分泌模式起作用。此外，B15的静息电位明显低于B16，并且含有较大的瞬态向外（类ia）电流。候选递质通过刺激或抑制控制进食的有层次组织的运动系统中每一级的元素来起作用。这扩大了可能由特定神经回路引起的行为反应的多样性。
We examined the effects of 3 neuropeptides and the bioactive amine 5-HT on identified motoneurons (B15 and B16) and interneurons (B4, B5) involved in the control of feeding behavior in Aplysia californica. The application of egg-laying hormone (ELH), small cardioactive peptide b (SCPb), and 5-HT elicits distinct patterns of synaptically induced bursting in the neurons, while PheMetArgPheamide (FMRFamide) inhibits firing due to synaptic activity. Repetitive IPSPs recorded in B15 and B16 are induced by 5-HT and SCPb and inhibited by FMRFamide. The substances also may act directly: In solutions that block synaptic transmission SCPb excites B15, ELH excites B16, 5-HT excites B15, B16, and B4, and FMRFamide both inhibits B15 and B16 and excites B4. We suggest that the output of a buccal ganglion central pattern generator may be modulated to produce distinct patterns of motoneuron activity by these candidate transmitters. We also noted differences in the intrinsic properties of the 2 motoneurons. B15 contains SCPb immunoreactivity while B16 does not. This finding suggests that B15 may be the source for the SCPb immunoreactivity previously found at the ARC muscle and that SCPb may be acting in an autocrine mode. Also, B15 has a significantly lower resting potential than B16 and contains a large transient outward (Ia-like) current. The candidate transmitters act by exciting or inhibiting elements at every level within the hierarchically organized motor system that controls feeding. This expands the diversity of behavioral repertoires that may be elicited from a particular neural circuit.
影响因子：
56.9
作者：
DELCOMYN, F
通讯作者：
DELCOMYN, F
海兔的节间脑颊机械传入：感受野和与参与进食行为的不同类别神经元的突触连接。
影响因子：
2.5
作者：
Rosen,SC;Weiss,KR;Cohen,JL;Kupfermann,I
通讯作者：
Kupfermann,I
原位杂交研究已识别神经元的起源和命运。
DOI：
10.1126/science.6356362
发表时间：
1983
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
McAllister,LB;Scheller,RH;Kandel,ER;Axel,R
通讯作者：
Axel,R