Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness.
Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness.
复制标题
干细胞。干性需要子细胞之间老化线粒体的不对称分配。
DOI：
10.1126/science.1260384
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发表时间：
2015-04-17
期刊：
影响因子：
--
通讯作者：
Sabatini DM
中科院分区：
文献类型：
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作者：
Katajisto P;Döhla J;Chaffer CL;Pentinmikko N;Marjanovic N;Iqbal S;Zoncu R;Chen W;Weinberg RA;Sabatini DM
通过不对称分裂，干细胞可以产生两个具有不同命运的子细胞。然而，在哺乳动物系统中，关于子细胞内容物在子代之间选择性分配的证据有限。我们追踪了人类乳腺干细胞分裂过程中年老和年轻细胞器的命运，发现这些细胞在子细胞之间不对称地分配老化的线粒体。接受较少旧线粒体的子细胞保持了干细胞特征。线粒体裂变的抑制破坏了线粒体的年龄依赖性亚细胞定位和分离，并导致子代细胞干细胞特性的丧失。因此，哺乳动物干细胞样细胞存在不对称分选衰老和年轻线粒体的机制，这对于维持干性特性非常重要。
By dividing asymmetrically, stem cells can generate two daughter cells with distinct fates. However, evidence is limited in mammalian systems for the selective apportioning of subcellular contents between daughters. We followed the fates of old and young organelles during the division of human mammary stem-like cells and found that such cells apportion aged mitochondria asymmetrically between daughter cells. Daughter cells that received fewer old mitochondria maintained stem cell traits. Inhibition of mitochondrial fission disrupted both the age-dependent sub-cellular localization and segregation of mitochondria, and caused loss of stem cell properties in the progeny cells. Hence, mechanisms exist for mammalian stem-like cells to asymmetrically sort aged and young mitochondria, and these are important for maintaining stemness properties.
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