Long-Term Changes in Drug Craving and Nutritional Status of Opioid Addicts with Nucleus Accumbens Ablative Stereotactic Neurosurgery at Five Years Postoperatively
Long-Term Changes in Drug Craving and Nutritional Status of Opioid Addicts with Nucleus Accumbens Ablative Stereotactic Neurosurgery at Five Years Postoperatively
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伏核消融立体定向神经外科术后五年阿片类药物成瘾者药物渴望和营养状况的长期变化
DOI：
10.1159/000441392
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发表时间：
2016-01
影响因子：
1.7
通讯作者：
Gao Guo-Dong
中科院分区：
文献类型：
--
作者：
Wu He-Ming;Ge Shun-Nan;Dai Hai-Bin;Wang Ling;Chang Chong-Wang;Wang Xue-Lian;Li Nan;Gao Guo-Dong
背景：伏隔核(NAcc)已被证明与药物和食物渴求有关。NACC消融性神经外科手术被认为可以调节大脑奖励系统的平衡，从而减轻患者的药物依赖。据推测，它还将缓解患者的食物渴望，并改变他们的营养状况。目的：本研究旨在评估NAcc神经外科手术对药物依赖患者术后5年的药物渴求和营养状况的影响。方法：本研究包括100例NAcc手术患者和92例非手术患者。检测体重指数(BMI)和体脂百分比(BF%)以评估营养状况，并采用问卷调查评估药物渴求。结果：与非手术组和手术组复发患者相比，手术组未复发患者的BMI和BF%较高，而对药物的渴求较低。非手术组与复发组BMI差异无统计学意义，但复发组药物渴求程度高于非手术组。结论：长期随访表明，如果个体持续戒断，NAcc去除性神经外科手术将缓解药物渴求并产生更好的营养状况。它会增加对药物的渴望，但不会破坏患者的营养状况，即使患者术后复发。
Background: The nucleus accumbens (NAcc) has been proven to be associated with drug and food craving. NAcc ablative neurosurgery has been suggested to modulate the balance of the brain reward system and thus alleviate drug dependence in patients. It has been hypothesized that it would also alleviate food craving in patients as well as altering their nutritional status. Aims: This study aimed to estimate the effect of NAcc neurosurgery on drug craving and nutritional status in patients with drug dependence at 5 years postoperatively. Methods: The study included 100 patients with NAcc surgery and 92 patients without surgery. Body mass index (BMI) and body fat percentage (BF%) were examined to assess nutritional status, and questionnaires were administered to assess drug craving. Results: Compared with the nonsurgery group and the relapse patients from the surgery group, the nonrelapse patients from the surgery group had higher BMI and BF% but lower drug craving. There were no significant differences between the nonsurgery group and the relapse patients in BMI, but the relapse patients had higher drug craving than the nonsurgery group. Conclusions: Long-term follow-up suggested that NAcc ablative neurosurgery would alleviate drug craving and yield a better nutritional status if individuals sustained abstinence. It would increase drug craving but would not ruin the nutritional status of patients even when individuals relapsed postoperatively.
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影响因子：
2.5
作者：
He-Ming Wu;Xuelian Wang;Chong-wang Chang;Nan Li;L. Gao;Ning Geng;Jiu-Hong Ma;Wei Zhao;G. Gao
通讯作者：
He-Ming Wu;Xuelian Wang;Chong-wang Chang;Nan Li;L. Gao;Ning Geng;Jiu-Hong Ma;Wei Zhao;G. Gao
DOI：
10.1523/jneurosci.15-10-06779.1995
发表时间：
1995-10
期刊：
--
影响因子：
--
作者：
CS Maldonado-Irizarry;CJ Swanson;A. Kelley
通讯作者：
CS Maldonado-Irizarry;CJ Swanson;A. Kelley
影响因子：
3.3
作者：
J. Woolley;B. Lee;H. Fields
通讯作者：
J. Woolley;B. Lee;H. Fields
影响因子：
3.6
作者：
Kagawa, M;Kerr, D;Binns, CW
通讯作者：
Binns, CW
影响因子：
4.2
作者：
Nederkoorn, Chantal;Houben, Katrijn;Jansen, Anita
通讯作者：
Jansen, Anita