The renin angiotensin system and the metabolic syndrome.
The renin angiotensin system and the metabolic syndrome.
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DOI：
10.1016/j.physbeh.2010.03.018
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发表时间：
2010-07-14
影响因子：
2.9
通讯作者：
Woods, Stephen C.
中科院分区：
文献类型：
--
作者：
de Kloet, Annette D.;Krause, Eric G.;Woods, Stephen C.
肾素血管紧张素系统（RAS;最为人所知的是其在心血管功能和水矿物质平衡调节中的关键作用）因其在代谢综合征的各个方面的潜在作用而重新受到关注。它可以作为肥胖和几种合并症之间的因果关系。减少血管紧张素-II（A-II; RAS的主要效应肽）的合成或作用的药物已被用于治疗高血压数十年，最近，临床试验已确定这些药理学药物预防胰岛素抵抗的效用。此外，有证据表明RAS通过在各种组织中起作用而有助于体重调节。本文综述了RAS在大脑和全身影响各种代谢紊乱的作用。特别强调RAS在体重调节中的作用。
The renin angiotensin system (RAS; most well-known for its critical roles in the regulation of cardiovascular function and hydromineral balance) has regained the spotlight for its potential roles in various aspects of the metabolic syndrome. It may serve as a causal link among obesity and several co-morbidities. Drugs that reduce the synthesis or action of angiotensin-II (A-II; the primary effector peptide of the RAS) have been used to treat hypertension for decades and, more recently, clinical trials have determined the utility of these pharmacological agents to prevent insulin resistance. Moreover, there is evidence that the RAS contributes to body weight regulation by acting in various tissues. This review summarizes what is known of the actions of the RAS in the brain and throughout the body to influence various metabolic disorders. Special emphasis is given to the role of the RAS in body weight regulation.
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影响因子：
13.5
作者：
Cuadra AE;Shan Z;Sumners C;Raizada MK
通讯作者：
Raizada MK
影响因子：
--
作者：
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通讯作者：
CASSIS, LA
影响因子：
158.5
作者：
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影响因子：
4.8
作者：
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通讯作者：
Kral, JG
DOI：
10.1038/oby.2005.235
发表时间：
2005-11-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Di Filippo, C;Lampa, E;D'Amico, M
通讯作者：
D'Amico, M