The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat.
The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat.
复制标题
绒山羊休止期-毛发生长初期毛囊转变过程中基因内mRNA-microRNA调控网络
DOI：
10.1038/s41598-018-31986-2
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发表时间：
2018-09-21
影响因子：
4.6
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Liu Z;Yang F;Zhao M;Ma L;Li H;Xie Y;Nai R;Che T;Su R;Zhang Y;Wang R;Wang Z;Li J
毛囊的周期性周期是由生物钟控制的，这一观点已被广泛接受，但毛囊周期的分子调控机制尚未得到深入研究。绒山羊的次级毛囊在其一生中具有季节性周期性变化的特点。在毛囊周期中，毛囊的起始对于毛囊的再生具有重要意义。本研究比较了绒山羊皮肤样品在生长期和静止期的mRNA和microRNA表达差异，为毛囊研究提供参考。通过microRNA和mRNA关联分析，我们发现了在毛囊起始中起主要调控作用的microRNA和靶基因。我们进一步构建了mRNA-microRNA相互作用网络，发现miR-195和CHP 1、SMAD 2、FZD 6和SIAH 1基因与毛囊的发生和发育相关。
It is widely accepted that the periodic cycle of hair follicles is controlled by the biological clock, but the molecular regulatory mechanisms of the hair follicle cycle have not been thoroughly studied. The secondary hair follicle of the cashmere goat is characterized by seasonal periodic changes throughout life. In the hair follicle cycle, the initiation of hair follicles is of great significance for hair follicle regeneration. To provide a reference for hair follicle research, our study compared differences in mRNA expression and microRNA expression during the growth and repose stages of cashmere goat skin samples. Through microRNA and mRNA association analysis, we found microRNAs and target genes that play major regulatory roles in hair follicle initiation. We further constructed an mRNA-microRNA interaction network and found that hair follicle initiation and development were related to MiR-195 and the genesCHP1,SMAD2,FZD6andSIAH1.
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DOI：
10.3724/sp.j.1005.2014.1235
发表时间：
2014-12-01
期刊：
Yichuan
影响因子：
--
作者：
Fu, Shaoyin;Zhao, Hongli;Zhang, Wenguang
通讯作者：
Zhang, Wenguang
WBSMDA：miRNA 疾病关联预测的评分内和评分之间
影响因子：
4.6
作者：
Chen X;Yan CC;Zhang X;You ZH;Deng L;Liu Y;Zhang Y;Dai Q
通讯作者：
Dai Q
影响因子：
3.5
作者：
Han P;Gopalakrishnan C;Yu H;Wang E
通讯作者：
Wang E
影响因子：
4.5
作者：
Chen, Xing;Niu, Ya-Wei;Yan, Gui-Ying
通讯作者：
Yan, Gui-Ying
影响因子：
48
作者：
Cloonan, Nicole;Forrest, Alistair R. R.;Grimmond, Sean M.
通讯作者：
Grimmond, Sean M.