High-resolution ion cyclotron mobility spectrometry.
High-resolution ion cyclotron mobility spectrometry.
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DOI：
10.1021/ac801880a
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发表时间：
2009-02-15
影响因子：
7.4
通讯作者：
Clemmer, David E.
中科院分区：
文献类型：
--
作者：
Merenbloom, Samuel I.;Glaskin, Rebecca S.;Henson, Zachary B.;Clemmer, David E.
介绍了一种新型离子迁移率谱仪，该仪器采用回旋加速器几何漂移管。漂移管由8个区域、4个弯曲漂移管和4个离子漏斗组成。通过改变漂移场的频率，离子包在漂移管周围传播，该频率与离子通过每个区域的漂移时间共振。这种方法在离子包离开和进入每个新区域时对其进行修整。静电栅允许离子在漂移管中保持多次循环，增加了解析特定离子的能力。我们通过分离P物质的[M+2H]2+或[M+3H]3+电荷态，以及从麻子糖和棉子糖的混合物中分离出单个三糖异构体来证明这种方法。用这种方法可以获得超过300的分辨力。
A novel ion mobility spectrometry instrument incorporating a cyclotron geometry drift tube is presented. The drift tube consists of eight regions, four curved drift tubes and four ion funnels. Packets of ions are propagated around the drift tube by changing the drift field at a frequency that is resonant with the ion’s drift time through each region. The approach trims each packet of ions as it leaves and enters each new region. An electrostatic gate allows ions to be kept in the drift tube for numerous cycles, increasing the ability to resolve specified ions. We demonstrate the approach by isolating the [M+2H]2+ or [M+3H]3+ charge state of substance P as well as individual trisaccharide isomers from a mixture of melezitose and raffinose. Resolving powers in excess of 300 are obtainable with this approach.
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影响因子：
1.3
作者：
COHEN, MJ;KARASEK, FW
通讯作者：
KARASEK, FW
影响因子：
15
作者：
Hudgins, RR;Ratner, MA;Jarrold, MF
通讯作者：
Jarrold, MF
影响因子：
7.4
作者：
Hoaglund, CS;Valentine, SJ;Clemmer, DE
通讯作者：
Clemmer, DE
影响因子：
--
作者：
Mesleh, MF;Hunter, JM;Jarrold, MF
通讯作者：
Jarrold, MF
影响因子：
7.4
作者：
Henderson, SC;Valentine, SJ;Clemmer, DE
通讯作者：
Clemmer, DE