Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.
Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.
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DOI：
10.1016/j.freeradbiomed.2017.10.341
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发表时间：
2018-01
影响因子：
7.4
通讯作者：
Mobley WC
中科院分区：
文献类型：
--
作者：
Chen XQ;Sawa M;Mobley WC
神经营养因子，包括神经营养因子家族的成员，在神经系统的发育和维持中起重要作用。营养因子信号必须从轴突和树突长距离传递到神经元的细胞体。非常适合于稳健的长距离信号传导的挑战的信号传导模式是信号传导内体。本文综述了信号内体的生物学和“信号内体假说”。在神经系统疾病的信号内体功能中断的证据也进行了审查。阿尔茨海默病（AD）和唐氏综合征（DS）的内体结构变化在这些疾病的早期就存在。负责的APP产品的数据进行了审查，并讨论了随之而来的变化，从内体信号。最后，我们指出，需要进一步的研究，以探讨正常神经元中的信号内体的生物学，并阐明其在神经退行性变的发病机制中的作用。
Neurotrophic factors, including the members of the neurotrophin family, play important roles in the development and maintenance of the nervous system. Trophic factor signals must be transmitted over long distances from axons and dendrites to the cell bodies of neurons. A mode of signaling well suited to the challenge of robust long distance signaling is the signaling endosome. We review the biology of signaling endosomes and the “signaling endosome hypothesis”. Evidence for disruption of signaling endosome function in disorders of the nervous system is also reviewed. Changes in endosome structure in Alzheimer disease (AD) and Down syndrome (DS) are present early in these disorders. Data for the APP products responsible are reviewed and the consequent changes in signaling from endosomes discussed. We conclude by pointing to the need for additional studies to explore the biology of signaling endosomes in normal neurons and to elucidate their role in the pathogenesis of neurodegeneration.
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影响因子：
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通讯作者：
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