The fps/fes tyrosine kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells and is localized in the trans-golgi network.
The fps/fes tyrosine kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells and is localized in the trans-golgi network.
复制标题
fps/fes 酪氨酸激酶在骨髓细胞、血管内皮细胞、上皮细胞和神经元细胞中表达，并且位于跨高尔基体网络中。
DOI：
--
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Peter A. Greer
中科院分区：
文献类型：
--
作者：
Jody J. Haigh;J. McVeigh;Peter A. Greer
fps/fes原癌基因编码细胞质蛋白酪氨酸激酶，其被认为参与涉及细胞因子受体超家族成员的信号传导途径，包括促红细胞生成素、粒细胞-巨噬细胞集落刺激因子、白血病抑制因子、制瘤素M、睫状神经营养因子和白细胞介素3、4、6和11。在造血细胞、血管内皮细胞和发育早期三个胚层的细胞类型中都检测到fps/fes的表达。在这里，我们描述了fps/fes在正常小鼠或过表达野生型或激活突变型fps/fes等位基因的转基因动物的发育和成年组织中的表达。在早期卵黄囊血岛的成血管细胞、软骨细胞、血管内皮细胞、神经元细胞和几种上皮细胞类型（包括脉络丛和子宫的上皮细胞）中发现了最高水平的fps/fes表达。Fps/Fes蛋白集中在培养的神经元，骨髓，上皮和血管内皮细胞的核周区域，和嵌合Fps/Fes绿色荧光蛋白与γ-适应蛋白，一个标记物的trans-Golgi装置共定位。这些观察结果表明参与Fps/Fes在囊泡运输过程中的细胞具有突出的分泌功能。
The fps/fes proto-oncogene encodes a cytoplasmic protein tyrosine kinase that is thought to participate in signaling pathways involving members of the cytokine receptor superfamily, including those for erythropoietin, granulocyte-macrophage colony-stimulating factor, leukemia inhibitory factor, oncostatin M, ciliary neurotropic factor, and interleukins 3, 4, 6, and 11. Expression of fps/fes has been detected in hematopoietic cells, vascular endothelial cells, and cell types arising from all three germ layers during early development. Here, we describe fps/fes expression in developing and adult tissues from normal mice or from transgenic animals overexpressing wild-type or activated mutant fps/fes alleles. The highest levels of fps/fes expression were seen in angioblasts of early yolk sac blood islands, chondrocytes, vascular endothelial cells, neuronal cells, and several epithelial cell types, including those of the choroid plexus and the uterus. Fps/Fes protein was concentrated in the perinuclear region of cultured neuronal, myeloid, epithelial, and vascular endothelial cells, and a chimeric Fps/Fes-green fluorescence protein colocalized with gamma-adaptin, a marker for the trans-Golgi apparatus. These observations suggest the involvement of Fps/Fes in vesicle transport processes in cells with prominent secretory functions.
登录
查看更多内容
p93c-fes 蛋白酪氨酸激酶体外磷酸化 ras GTP 酶激活蛋白 (GAP)，并通过 SH2 结构域依赖性机制形成 GAP-fes 复合物。
影响因子：
2.9
作者：
Hjermstad,SJ;Briggs,SD;Smithgall,TE
通讯作者：
Smithgall,TE
DOI：
10.1164/ajrccm/140.4.1097
发表时间：
1989-10-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
NODEN, DM
通讯作者：
NODEN, DM
通过 src 同源 2 结构域和主要自磷酸化位点 (Tyr-713) 调节人 c-fes 蛋白酪氨酸激酶 (p93c-fes)。
影响因子：
8
作者：
Hjermstad,SJ;Peters,KL;Briggs,SD;Glazer,RI;Smithgall,TE
通讯作者：
Smithgall,TE
磷脂酰肌醇-3 激酶在 v-src、v-yes 和 v-fps 转化的鸡胚成纤维细胞中被激活。
影响因子：
8
作者：
Fukui,Y;Saltiel,AR;Hanafusa,H
通讯作者：
Hanafusa,H
人类 c-FES 是一种核酪氨酸激酶。
影响因子：
8
作者：
Yates,KE;Lynch,MR;Wong,SG;Slamon,DJ;Gasson,JC
通讯作者：
Gasson,JC