Aperiodic electrophysiological activity in preterm infants is linked to subsequent autism risk.
Aperiodic electrophysiological activity in preterm infants is linked to subsequent autism risk.
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DOI：
10.1002/dev.22271
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发表时间：
2022-05
影响因子：
2.2
通讯作者：
中科院分区：
文献类型：
--
作者：
大约7%的早产儿被诊断为ASD。然而，在确定早产儿神经发育风险的预期标记物方面，文献中存在着显著的差距。本研究在南非不同的早产儿队列中检测了婴儿期的两个脑电(EEG)参数，绝对脑电功率和功率谱密度(PSD)斜率的非周期活动与随后的自闭症风险和认知能力的关系。研究对象为早产儿71例，胎龄25~36周，平均(34.60±2.34)周。EEG采集时间为39~41周，调整后为(40.00±0.42)周。在调整后的3岁左右(34±2.7个月)进行贝利婴幼儿发展量表和简明婴幼儿社会情绪评估(BITSEA)。在三岁时，多个电极位置的非周期性活动，而不是节律性振荡活动，与随后BITSEA上自闭症风险的增加有关。没有发现PSD斜率或绝对脑电功率与认知发展之间的关联。我们的发现强调了在高危人群中检查后续自闭症风险的潜在标记物的必要性，而不是处于家庭风险中的婴儿。
Approximately 7% of preterm infants receive an ASD diagnosis. Yet, there is a significant gap in the literature in identifying prospective markers of neurodevelopmental risk in preterm infants. The present study examined two electroencephalography (EEG) parameters during infancy, absolute EEG power and aperiodic activity of the power spectral density (PSD) slope in association with subsequent autism risk and cognitive ability in a diverse cohort of children born preterm in South Africa. Participants were 71 preterm infants born between 25 and 36 weeks gestation (34.60 ± 2.34 weeks). EEG was collected during sleep between 39 and 41 weeks postmenstrual age adjusted (40.00 ± 0.42 weeks). The Bayley Scales of Infant Development and Brief Infant Toddler Social Emotional Assessment (BITSEA) were administered at approximately three years of age adjusted (34 ± 2.7 months). Aperiodic activity, but not the rhythmic oscillatory activity, at multiple electrode sites was associated with subsequent increased autism risk on the BITSEA at three years of age. No associations were found between the PSD slope or absolute EEG power and cognitive development. Our findings highlight the need to examine potential markers of subsequent autism risk in high-risk populations other than infants at familial risk.
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影响因子：
2.1
作者：
Bhat, A. N.;McDonald, N. M.;Pelphrey, K. A.
通讯作者：
Pelphrey, K. A.
DOI：
10.1155/2017/1631760
发表时间：
2017-01-01
期刊：
International scholarly research notices
影响因子：
--
作者：
Ballot, Daynia E;Ramdin, Tanusha;Cooper, Peter A
通讯作者：
Cooper, Peter A
影响因子：
4.7
作者：
Clarke, AR;Barry, RJ;Selikowitz, M
通讯作者：
Selikowitz, M
影响因子：
4.7
作者：
Dustman, RE;Shearer, DE;Emmerson, RY
通讯作者：
Emmerson, RY
影响因子：
2.5
作者：
Gray, Peter H.;Edwards, Dawn M.;Gibbons, Kristen
通讯作者：
Gibbons, Kristen