Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder.
Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder.
复制标题
血清素转运蛋白多聚腺苷酸化多态性与恐慌症的关联。
DOI：
10.1016/j.biopsych.2009.10.015
复制
发表时间：
2010-02-15
影响因子：
10.6
通讯作者：
Glatt CE
中科院分区：
文献类型：
--
作者：
Gyawali S;Subaran R;Weissman MM;Hershkowitz D;McKenna MC;Talati A;Fyer AJ;Wickramaratne P;Adams PB;Hodge SE;Schmidt CJ;Bannon MJ;Glatt CE
血清素转运蛋白中的遗传标记与恐慌症有关。相关的多态性不包括血清素转运蛋白连接的多态性区域并且没有表现出明显的功能属性。常见的多态性 (rs3813034) 发生在两个报道的血清素转运蛋白多腺苷酸化信号之一中，并且与恐慌症相关标记连锁不平衡。如果功能正常，rs3813034 可能是解释血清素转运蛋白与恐慌症之间关系的危险因素。使用人脑样本 (n=65) 和淋巴母细胞培养物 (n=71) 的定量 PCR 来测试 rs3813034 对血清素转运蛋白多腺苷酸化形式表达的影响。还测试了 rs3813034 与恐慌症病例样本 (n=307) 和具有相似群体结构的对照样本 (n=542) 的关联。血清素转运蛋白的两种多腺苷酸化形式的平衡与脑（P<0.001）和淋巴母细胞（P<0.001）中的rs3813034相关。多腺苷酸化形式的平衡也仅与大脑中的性别相关（P<0.05）。惊恐障碍中 rs3813034 的关联测试发现，杂合和纯合变异基因型的相对风险分别为 1.56 和 1.81，具有显着关联（P=0.0068）。 rs3813034 是血清素转运蛋白中的功能多态性，可改变血清素转运蛋白的两种聚腺苷酸化形式的平衡。 rs3813034 是恐慌症和其他涉及血清素神经传递失调的行为障碍的假定危险因素。
Genetic markers in the serotonin transporter are associated with panic disorder. The associated polymorphisms do not include the serotonin transporter-linked polymorphic region and display no obvious functional attributes. A common polymorphism (rs3813034) occurs in one of the two reported polyadenylation signals for the serotonin transporter and is in linkage disequilibrium with the panic disorder-associated markers. If functional, rs3813034 may be the risk factor that explains the association of the serotonin transporter and panic disorder. Quantitative PCR on human brain samples (n=65) and lymphoblast cultures (n=71) was used to test rs3813034 for effects on expression of the polyadenylation forms of the serotonin transporter. rs3813034 was also tested for association in a sample of panic disorder cases (n=307) and a control sample (n=542) that has similar population structure. The balance of the two polyadenylation forms of the serotonin transporter is associated with rs3813034 in brain (P<0.001) and lymphoblasts (P<0.001). The balance of the polyadenylation forms is also associated with gender in brain only (P<0.05). Association testing of rs3813034 in panic disorder identified a significant association (P=0.0068) with a relative risk of 1.56 and 1.81 for the heterozygous and homozygous variant genotypes respectively. rs3813034 is a functional polymorphism in the serotonin transporter that alters the balance of the two polyadenylation forms of the serotonin transporter. rs3813034 is a putative risk factor for panic disorder and other behavioral disorders that involve dysregulation of serotonergic neurotransmission.
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影响因子：
10.6
作者：
Holmes, A;Murphy, DL;Crawley, JN
通讯作者：
Crawley, JN
DOI：
10.1016/0169-328x(94)00219-5
发表时间：
1995-02-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
KINGSBURY, AE;FOSTER, OJF;MARSDEN, CD
通讯作者：
MARSDEN, CD
影响因子：
7.6
作者：
Holmes, A;Yang, RJ;Crawley, JN
通讯作者：
Crawley, JN
影响因子：
56.9
作者：
Hariri, AR;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
7.6
作者：
Albertson, Dawn N.;Schmidt, Carl J.;Bannon, Michael J.
通讯作者：
Bannon, Michael J.