Regulation of FGF soluble receptor type 1 (SR1) expression and distribution in developing, degenerating, and FGF2‐treated retina
Regulation of FGF soluble receptor type 1 (SR1) expression and distribution in developing, degenerating, and FGF2‐treated retina
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发育、退化和 FGF2 处理的视网膜中 FGF 可溶性受体 1 (SR1) 表达和分布的调节
DOI：
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发表时间：
2000
影响因子：
2.5
通讯作者：
F. Mascarelli
中科院分区：
文献类型：
--
作者：
X. Guillonneau;F. Régnier‐Ricard;J. Jeanny;S. Thomasseau;Y. Courtois;F. Mascarelli
本文研究了成纤维细胞生长因子（FGF）可溶性受体SR 1（一种FGF特异性抑制剂）在Fisher大鼠胚胎期和出生后视网膜发育过程中表达和含量的时空模式。早在胚胎第18天（E18），SR 1 mRNA和蛋白在视网膜中的检测。SR 1蛋白与神经节细胞的分化密切相关，其分布呈放射状，从中心到周边。从E18到出生后5天，SR 1 mRNA和SR 1蛋白的水平保持恒定。此后，它们迅速下降，在成人视网膜中下降了5倍。SR 1在内核层被标记，但从未在感光细胞核。RCS营养不良大鼠视网膜SR 1 mRNA和蛋白表达水平在光感受器变性前和变性过程中均比正常对照组高2 ~ 3倍。这些结果提供了第一个证据表明，天然FGF抑制剂在视网膜发育和变性过程中受到调节，并表明SR 1含量的变化可能参与视网膜FGF活性的调节。这在RCS大鼠体内得到了证实，其中玻璃体内注射FGF 2导致的感光细胞凋亡延迟伴随着SR 1表达的下调。Dev Dyn 2000;217：24-36.© 2000 Wiley利斯公司
The spatial and temporal patterns of expression and content of the fibroblast growth factor (FGF) soluble receptor SR1, a specific inhibitor of FGF, were investigated during embryonic and postnatal development of the retina in Fisher rats. As early as at embryonic day 18 (E18), SR1 mRNA and protein were detected in the retina. SR1 protein was strongly associated with the differentiating ganglion cells and its distribution paralleled the radial pattern of retinal development, from center to periphery. From E18 to postnatal day 5, the levels of both SR1 mRNA and SR1 protein remained constant. Thereafter, they decreased rapidly, by a factor of 5 in the adult retina. SR1 was labeled in the inner nuclear layer, but never in the photoreceptor nuclei. In the neural retina of RCS dystrophic rats, the levels SR1 mRNA and SR1 protein were 2 to 3 times higher than those in the normal congenic controls, before and during photoreceptor degeneration. These results provide the first evidence that a natural FGF inhibitor is regulated during retina development and degeneration and suggest that changes in SR1 content may be involved in the regulation of FGF activities in retina. This was confirmed in vivo in RCS rats, in which delayed photoreceptor apoptosis by intravitreal injection of FGF2 was accompanied by a downregulation of SR1 expression. Dev Dyn 2000;217:24–36. © 2000 Wiley‐Liss, Inc.
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影响因子：
4.6
作者：
A. Wanaka;J. Milbrandt;Eugene M. Johnson
通讯作者：
A. Wanaka;J. Milbrandt;Eugene M. Johnson
细胞外 FGF-1 在转基因小鼠中充当晶状体分化因子。
DOI：
10.1242/dev.121.2.505
发表时间：
1995
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Robinson,ML;Overbeek,PA;Verran,DJ;Grizzle,WE;Stockard,CR;Friesel,R;Maciag,T;Thompson,JA
通讯作者：
Thompson,JA
影响因子：
56.9
作者：
LEE, PL;JOHNSON, DE;WILLIAMS, LT
通讯作者：
WILLIAMS, LT
味蕾从内胚层自主发育，无需头神经嵴或轴旁中胚层的诱导。
DOI：
10.1242/dev.124.5.949
发表时间：
1997
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Barlow,LA;Northcutt,RG
通讯作者：
Northcutt,RG
影响因子：
4.6
作者：
François Guillemot;Constance L. Cepko
通讯作者：
François Guillemot;Constance L. Cepko