Molecular imaging-based dose painting: a novel paradigm for radiation therapy prescription.
Molecular imaging-based dose painting: a novel paradigm for radiation therapy prescription.
复制标题
DOI：
10.1016/j.semradonc.2010.10.001
复制
发表时间：
2011-04
影响因子：
3.5
通讯作者：
Gregoire, Vincent
中科院分区：
文献类型：
--
作者：
Bentzen, Soren M.;Gregoire, Vincent
剂量绘制是基于显示为指示局部复发风险的功能或分子图像，对靶体积的非均匀辐射剂量分布的处方。两个原型的策略，实现这种新的范例在放射肿瘤学：子体积提升和剂量绘画的数字。子体积增强涉及“目标内的目标”的选择，其通过基于图像中的定量信息或形态学上的图像分割来定义，并且这与基于图像的目标体积选择和描绘有关。数字剂量绘制是基于单个像素的图像强度的数学变换的体素级剂量处方。定量使用图像来决定在个体病例中在何处以及如何递送放射治疗也被称为治疗诊断成像。剂量绘制靶点是与放射反应性差相关的细胞或微环境表型的成像替代物。在这篇综述中，重点是正电子发射断层扫描（PET）示踪剂：FDG和胆碱作为肿瘤负荷的替代品，FLT作为增殖（或细胞生长分数）的替代品和缺氧敏感的示踪剂，包括FMISO，EF 3，EF 5和Cu-ATSM作为细胞缺氧的替代品。支持剂量绘画的临床生物学原理的研究进展进行审查，是优化和提供现实的剂量绘画放射治疗计划的技术可行性的研究。在这个令人兴奋的研究领域的挑战和研究重点的定义和剂量绘画的随机临床试验的可能设计。
Dose painting is the prescription of a non-uniform radiation dose distribution to the target volume based on functional or molecular images shown to be indicative of the local risk of relapse. Two prototypical strategies for implementing this novel paradigm in radiation oncology are reviewed: sub-volume boosting and dose painting by numbers. Sub-volume boosting involves the selection of a “target within the target”, defined by image segmentation on the basis of the quantitative information in the image or morphologically, and this is related to image based target volume selection and delineation. Dose painting by numbers is a voxel-level prescription of dose based on a mathematical transformation of the image intensity of individual pixels. Quantitative use of images to decide both where and how to delivery radiation therapy in an individual case is also called theragnostic imaging. Dose painting targets are imaging surrogates for cellular or microenvironmental phenotypes associated with poor radioresponsiveness. In this review, the focus is on positron emission tomography (PET) tracers: FDG and choline as surrogates for tumor burden, FLT as a surrogate for proliferation (or cellular growth fraction) and hypoxia sensitive tracers including FMISO, EF3, EF5 and Cu-ATSM as surrogates of cellular hypoxia. Research advances supporting the clinico-biological rationale for dose painting are reviewed as are studies of the technical feasibility of optimizing and delivering realistic dose painted radiation therapy plans. Challenges and research priorities in this exciting research field are defined and a possible design for a randomized clinical trial of dose painting is presented.
登录
查看更多内容
影响因子：
11.5
作者：
Apisarnthanarax, Smith;Alauddin, Mian M.;Chao, K. S. Clifford
通讯作者：
Chao, K. S. Clifford
DOI：
10.1016/j.ijrobp.2003.09.043
发表时间：
2004-02-01
影响因子：
7
作者：
Eriksen, JG;Steiniche, T;Overgaard, J
通讯作者：
Overgaard, J
影响因子：
51.1
作者：
Bentzen, SM
通讯作者：
Bentzen, SM
影响因子：
158.5
作者：
Bonner, JA;Harari, PM;Ang, KK
通讯作者：
Ang, KK
DOI：
10.1007/s00259-008-0888-9
发表时间：
2008-12-01
影响因子：
9.1
作者：
Busk, Morten;Horsman, Michael R.;Overgaard, Jens
通讯作者：
Overgaard, Jens