Chk'ing p53-deficient breast cancers.
Chk'ing p53-deficient breast cancers.
复制标题
检测 p53 缺陷型乳腺癌。
DOI：
10.1172/jci63205
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Brown,EricJ
中科院分区：
文献类型：
--
作者：
Schoppy,DavidW;Brown,EricJ
Loss or functional impairment of p53 occurs in many human cancers, and its absence is often associated with a poor response to conventional chemotherapy. Hence, much effort is currently devoted to developing novel treatments for p53-deficient malignancies. One approach is to target pathways that are selectively required for the survival of p53-deficient cancer cells, thus exploiting a synthetic lethal interaction. Previous studies have demonstrated that inhibition of the ataxia telangiectasia and Rad3-related (ATR) and checkpoint kinase 1 (Chk1) pathway in p53-deficient cells can induce such a synthetic lethal outcome. In this issue of theJCI, Ma et al. take these findings a step closer to the clinic by demonstrating that highly specific inhibitors of Chk1 synergize with chemotherapy to stem progression of p53-deficient triple-negative breast cancers in a xenotransplant model of this disease. Together with other recent studies, this report highlights the promise of ATR and Chk1 inhibitors in targeted cancer treatment.
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影响因子：
11.2
作者：
K. Russell;Wiens Lw;G. Demers;D. Galloway;Plon Se;M. Groudine
通讯作者：
K. Russell;Wiens Lw;G. Demers;D. Galloway;Plon Se;M. Groudine
影响因子：
23.9
作者：
Ruzankina, Yaroslava;Pinzon-Guzman, Carolina;Brown, Eric J.
通讯作者：
Brown, Eric J.
影响因子：
16.8
作者：
Toledo LI;Murga M;Zur R;Soria R;Rodriguez A;Martinez S;Oyarzabal J;Pastor J;Bischoff JR;Fernandez-Capetillo O
通讯作者：
Fernandez-Capetillo O
影响因子：
11.2
作者：
S. Powell;J. DeFrank;Paul Connell;M. Eogan;FredericI. Preffer;D. Dombkowski;Wei Tang;S. Friend
通讯作者：
S. Powell;J. DeFrank;Paul Connell;M. Eogan;FredericI. Preffer;D. Dombkowski;Wei Tang;S. Friend
影响因子：
13.6
作者：
Ma CX;Janetka JW;Piwnica-Worms H
通讯作者：
Piwnica-Worms H