Mechanism Research and Application for Ginsenosides in the Treatment of Hepatocellular Carcinoma.
Mechanism Research and Application for Ginsenosides in the Treatment of Hepatocellular Carcinoma.
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DOI：
10.1155/2023/7214037
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发表时间：
2023
影响因子：
--
通讯作者：
Cheng, Shuqun
中科院分区：
文献类型：
--
作者：
Zhou, Nian;Mao, Feifei;Cheng, Shuqun
人参皂苷是人参的主要活性药理成分，广泛应用于多种癌症的治疗。肝细胞癌是世界范围内死亡率居第三位的恶性肿瘤。越来越多的证据表明，人参皂苷在肝癌的防治中起着至关重要的作用。人参皂苷可显著改善肝癌的症状，其抗癌活性主要涉及抑制细胞增殖和迁移，诱导细胞周期停滞于G0/G1期，促进caspase-3和8介导的细胞凋亡，调节与ATG5、ATG7、ATG12、Lc3-II和PI3K/Akt通路相关的自噬，减少与核移位相关的侵袭和转移，增加IL-2和κ-γ水平以增强免疫功能，以及调节肠肝轴。此外，人参皂苷还可以作为传统癌症治疗的佐剂，增强对化疗药物的敏感性，并通过协同作用提高疗效和/或减少不良反应。因此，本文就人参皂苷在肝细胞癌中的作用机制及应用进行综述。希望为人参皂苷治疗肝癌提供理论依据。
Ginsenosides, the main active pharmacological ingredients of ginseng, have been widely used for the treatment of numerous carcinomas. Hepatocellular carcinoma (HCC) is 3rd leading malignant tumor in terms of mortality worldwide. Accumulating evidence indicates that ginsenosides play a vital role in the prevention and treatment of HCC. Ginsenosides can significantly improve the symptoms of HCC, and their anticancer activity is mainly involved in inhibiting proliferation and migration, inducing cell cycle arrest at the G0/G1 phase, promoting caspase-3 and 8-mediated apoptosis, regulating autophagy related to Atg5, Atg7, Atg12, LC3-II, and PI3K/Akt pathways, and lowering invasion and metastasis associated with decreased nuclear translocation of NF-κB p65 and MMP-2/9, increasing IL-2 and IFN-γ levels to enhance immune function, as well as regulating the gut-liver axis. In addition, ginsenosides can be used as an adjuvant to conventional cancer therapies, enhancing sensitivity to chemotherapy drugs, and improving efficacy and/or reducing adverse reactions through synergistic effects. Therefore, the current manuscript discusses the mechanism and application of ginsenosides in HCC. It is hoped to provide theoretical basis for the treatment of HCC with ginsenosides.
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