Targeting the Lipid Metabolic Pathways for the Treatment of Malaria.
Targeting the Lipid Metabolic Pathways for the Treatment of Malaria.
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DOI：
10.1002/ddr.20347
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发表时间：
2010-02
影响因子：
3.8
通讯作者：
Vial, Henri
中科院分区：
文献类型：
--
作者：
Ben Mamoun, Choukri;Prigge, Sean T.;Vial, Henri
控制并最终根除人类疟疾被认为是21世纪最重要的全球公共卫生目标之一。疟疾由疟原虫属的红细胞内原生动物寄生虫引起，是迄今为止最致命和最流行的传染病之一。已知四种疟原虫（恶性疟原虫、疟疾疟原虫、卵形疟原虫和间日疟原虫）对人类具有传染性，最近也报告了因诺氏疟原虫感染的病例。这些物种每年造成约3亿例临床疟疾病例，其中约100万人死亡，主要由恶性疟原虫引起。耐药疟原虫菌株的迅速出现严重降低了通常用于治疗和阻止疟疾传播的药物的效力，并威胁到该领域联合治疗的有效性。迫切需要针对寄生虫重要功能的新药，这些药物不是目前抗疟药物的目标，并且有可能对多重耐药的疟原虫菌株起作用。最近对恶性疟原虫的研究揭示了疟原虫磷脂和脂肪酸合成的新代谢途径。本综述总结了我们目前对这些途径在疟原虫发展和发病机制中的理解，并提供了正在进行的利用遗传手段表征其重要性和开发针对脂质代谢途径的抗疟疾疗法的最新进展。
The control and eventual eradication of human malaria is considered one of the most important global public health goals of the 21st Century. Malaria, caused by intraerythrocytic protozoan parasites of the genus Plasmodium, is by far the most lethal and among the most prevalent of the infectious diseases. Four species of Plasmodium (P. falciparum, P. malariae, P. ovale, and P. vivax) are known to be infectious to humans, and more recent cases of infection due to P. knowlesi also have been reported. These species cause approximately 300 million annual cases of clinical malaria resulting in around one million deaths mostly caused by P. falciparum. The rapid emergence of drug-resistant Plasmodium strains has severely reduced the potency of medicines commonly used to treat and block the transmission of malaria and threatens the effectiveness of combination therapy in the field. New drugs that target important parasite functions, which are not the target of current antimalarial drugs, and have the potential to act against multi-drug-resistant Plasmodium strains are urgently needed. Recent studies in P. falciparum have unraveled new metabolic pathways for the synthesis of the parasite phospholipids and fatty acids. The present review summarizes our current understanding of these pathways in Plasmodium development and pathogenesis, and provides an update on the efforts underway to characterize their importance using genetic means and to develop antimalarial therapies targeting lipid metabolic pathways.
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1.5
作者：
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