Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study.
Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study.
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DOI：
10.1167/iovs.08-2228
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发表时间：
2008-12
影响因子：
4.4
通讯作者：
Allingham RR
中科院分区：
文献类型：
--
作者：
Berdahl JP;Fautsch MP;Stinnett SS;Allingham RR
比较原发性开角型青光眼（POAG）、正常眼压性青光眼（NTG; POAG的子集）和高眼压症（OHT）受试者与非青光眼受试者的颅内压（ICP）。这项研究是对1985年至2007年在马约诊所接受腰椎穿刺的62,468名受试者的病历进行回顾性分析。其中，57例POAG受试者、11例NTG受试者（POAG子集）、27例OHT受试者和105例对照受试者符合标准并进行了分析。通过单变量和多变量分析，对ICP与其他眼部和非眼部变量之间的关系进行了盲法比较。与年龄匹配的无青光眼对照组相比，POAG患者的ICP显著降低（9.1 ± 0.77 mm Hg vs. 11.8 ± 0.71 mm Hg; P < 0.0001）。NTG组ICP较对照组降低（8.7 ± 1.16 mm Hg vs.11.8 ± 0.71 mm Hg; P < 0.01）。OHT组ICP高于年龄匹配的对照组（12.6 ± 0.85 mm Hg vs. 10.6 ± 0.81 mm Hg; P < 0.05）。ICP在POAG和NTG中较低，而在OHT中升高。ICP可能在POAG和NTG的发展中起重要作用，并在阻止OHT向POAG的进展中起重要作用。进一步的前瞻性和实验性研究是必要的，以确定ICP是否在青光眼的发病机制中起着重要作用。
To compare intracranial pressure (ICP) in subjects with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG; subset of POAG), and ocular hypertension (OHT) with that in subjects with no glaucoma. The study was a retrospective review of medical records of 62,468 subjects who had lumbar puncture between 1985 and 2007 at the Mayo Clinic. Of these, 57 POAG subjects, 11 NTG subjects (subset of POAG), 27 OHT subjects, and 105 control subjects met the criteria and were analyzed. A masked comparison of the relationship between ICP and other ocular and nonocular variables was performed by using univariate and multivariate analyses. ICP was significantly lower in POAG compared with age-matched control subjects with no glaucoma (9.1 ± 0.77 mm Hg vs. 11.8 ± 0.71 mm Hg; P < 0.0001). Subjects with NTG also had reduced ICP compared with the control subjects (8.7 ± 1.16 mm Hg vs. 11.8 ± 0.71 mm Hg; P < 0.01). ICP was higher in OHT than in age-matched control subjects (12.6 ± 0.85 mm Hg vs. 10.6 ± 0.81 mm Hg; P < 0.05). ICP is lower in POAG and NTG and elevated in OHT. ICP may play an important role in the development of POAG and NTG and in preventing the progression of OHT to POAG. Further prospective and experimental studies are warranted to determine whether ICP has a fundamental role in the pathogenesis of glaucoma.
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影响因子：
4.1
作者：
Garway-Heath, DF;Poinoosawmy, D;Hitchings, RA
通讯作者：
Hitchings, RA
影响因子：
4.2
作者：
Quigley, HA;Tielsch, JM;Sommer, A
通讯作者：
Sommer, A
影响因子：
3
作者：
Carlson, GD;Oliff, HS;Anderson, PA
通讯作者：
Anderson, PA
DOI：
10.1111/j.1748-1716.1980.tb06575.x
发表时间：
1980-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
HAHNENBERGER, RW
通讯作者：
HAHNENBERGER, RW
DOI：
10.1073/pnas.68.6.1279
发表时间：
1971-01-01
影响因子：
11.1
作者：
OCHS, S
通讯作者：
OCHS, S