Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation.
Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation.
复制标题
增生性 ACF 出现腺瘤性异常隐窝病灶 (ACF)，并伴随细胞增殖增加。
作者：
K. Otori;K. Sugiyama;T. Hasebe;Shoji Fukushima;H. Esumi
为探讨异常隐窝病灶（ACF）与结直肠癌发生的关系，我们对57例结直肠癌手术标本中的433个ACF进行了评估。ACF的大小范围为3至412个异常隐窝/病灶。大ACF（≥ 50个隐窝/病灶）占研究的ACF总数的25%。组织学检查，65%（67/103）的大型ACF被诊断为增生，10%（10/103）为腺瘤，1%（1/103）为正常结直肠粘膜。其余24%（25/103）被诊断为“I期异常隐窝”，其特征是增殖区室延伸至隐窝表面，但主要增殖部位无变化，如E. E. Deschner [Pathol. Annu.，18（Part 1）：205-219，1983]。25例I期异常ACF中，7例ACF伴增生。在10例腺瘤性ACF中，2例与I期异常隐窝共存。在85%（93/109）的大型ACF中发现了K-ras密码子12突变。在同一ACF中，I期隐窝的增殖活性明显高于增生隐窝。这些观察结果表明，一些增生性ACF可能发展成腺瘤性ACF的方式，I期异常ACF伴随收购更高的增殖活性，通过一些遗传和/或表观遗传的变化。
To investigate the relationship between aberrant crypt foci (ACF) and colon neoplasia in colorectal carcinogenesis, we evaluated 433 ACF, which were collected from the grossly normal mucosa of surgical specimens from 57 patients with colorectal cancer. The ACF ranged in size from 3 to 412 aberrant crypts/focus. Large ACF (> or = 50 crypts/focus) comprised 25% of the total ACF studied. Histopathologically, 65% (67 of 103) of large ACF were diagnosed as hyperplasia, 10% (10 of 103) as adenoma, and 1% (1 of 103) as within normal colorectal mucosa. The remaining 24% (25 of 103) were diagnosed as "stage I abnormality crypts," which were characterized by their extension of the proliferative compartment to the surface of crypts but with no changes in the major site of proliferation, as designated by E. E. Deschner [Pathol. Annu., 18 (Part 1): 205-219, 1983]. Of the 25 stage I abnormality ACF, 7 ACF coexisted with hyperplasia. Of 10 adenomatous ACF, two coexisted with stage I abnormality crypts. A K-ras codon 12 mutation was identified in 85% (93 of 109) of large ACF. The proliferative activity of stage I crypts was significantly higher than that of hyperplastic crypts in the same ACF. These observations suggest that some hyperplastic ACF may develop into adenomatous ACF by way of stage I abnormality ACF with concomitant acquisition of higher proliferative activity through some genetic and/or epigenetic changes.
结直肠病变发育不良的分子决定因素。
影响因子：
11.2
作者：
Jen,J;Powell,SM;Papadopoulos,N;Smith,KJ;Hamilton,SR;Vogelstein,B;Kinzler,KW
通讯作者：
Kinzler,KW
影响因子：
11.2
作者：
T. P. Pretlow;B. J. Barrow;VV. Scott Ashton;M. O'riordan;T. Pretlow;J. Jurcisek;T. Stellato
通讯作者：
T. P. Pretlow;B. J. Barrow;VV. Scott Ashton;M. O'riordan;T. Pretlow;J. Jurcisek;T. Stellato