Outcomes of patients with blastoid and pleomorphic variant mantle cell lymphoma.
Outcomes of patients with blastoid and pleomorphic variant mantle cell lymphoma.
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DOI：
10.1182/bloodadvances.2023010757
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发表时间：
2023-12-26
期刊：
影响因子：
7.5
通讯作者：
Barta, Stefan K.
中科院分区：
文献类型：
--
作者：
Gerson, James N.;Handorf, Elizabeth;Villa, Diego;Gerrie, Alina S.;Chapani, Parv;Li, Shaoying;Medeiros, Jeffrey;Wang, Michael;Cohen, Jonathon B.;Churnetski, Michael;Hill, Brian T.;Sawalha, Yazeed;Hernandez-Ilizaliturri, Francisco J.;Kothari, Shalin;Vose, Julie M.;Bast, Martin;Fenske, Timothy;Gari, Swapna Narayana Rao;Maddocks, Kami J.;Bond, David;Bachanova, Veronika;Kolla, Bhaskar;Chavez, Julio;Shah, Bijal;Lansigan, Frederick;Burns, Timothy;Donovan, Alexandra M.;Wagner-Johnston, Nina;Messmer, Marcus;Mehta, Amitkumar;Anderson, Jennifer K.;Reddy, Nishitha;Kovach, Alexandra E.;Landsburg, Daniel J.;Glenn, Martha;Inwards, David J.;Ristow, Kay;Karmali, Reem;Kaplan, Jason B.;Caimi, Paolo F.;Rajguru, Saurabh;Evens, Andrew;Klein, Andreas;Umyarova, Elvira;Pulluri, Bhargavi;Amengua, Jennifer E.;Lue, Jennifer K.;Diefenbach, Catherine;Fisher, Richard I.;Barta, Stefan K.
母细胞样和多形性变异型 MCL 患者的预后不佳。接受自动 HCT、MIPI 评分和诱导完全缓解与 PFS 相关；自动 HCT 与 OS 无关。套细胞淋巴瘤 (MCL) 是一种 B 细胞非霍奇金淋巴瘤；数据表明，母细胞和多形性变异的预后较差。我们报告了 MCL 母细胞样/多形性变异患者的特征和结果。我们回顾性研究了 2000 年至 2015 年间接受治疗的新诊断 MCL 成人。主要目标是描述无进展生存期 (PFS) 和总生存期 (OS)。次要目标包括患者特征和治疗的表征。在研究的 1029 名 MCL 患者中，共有 207 例肿瘤为母细胞或多形性变异。中位随访期为 82 个月（范围：0.1-174 个月）；中位 PFS 为 38 个月（95% 置信区间 [CI]，28-66），OS 为 68 个月（95% CI，45-96）。与 PFS 相关的因素包括接受巩固性自体造血移植（自体 HCT；风险比 [HR]，0.52；95% CI，0.31-0.80；P < .05）、MCL 国际预后指数 (MIPI) 中等（HR，2.3；95% CI，1.2-4.3；P < .02）和高（HR， 3.8；95% CI，2.0-7.4；P < .01）评分和诱导完全缓解（HR，0.29（95% CI，0.17-0.51）。接受自动 HCT 与 OS 无关（HR，0.69；95% CI，0.41-1.16；P = .16），但与 MIPI 相关中等（HR，5.7；95% CI，2.5-13.2；P < .01）和高（HR，10.8；95% CI，4.7-24.9；P < .01）评分。我们报告了一大群患有母细胞样/多形性变异 MCL 的患者的结果。对于符合条件的患者，诱导后接受自动 HCT 与改善 PFS 相关，但与较高 MIPI 无关。评分和自动 HCT 不合格与较差的生存率相关。
Patients with blastoid and pleomorphic variant MCL have suboptimal outcomes. Receipt of auto-HCT, MIPI score, and complete response to induction were associated with PFS; auto-HCT was not associated with OS. Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma; data indicate that blastoid and pleomorphic variants have a poor prognosis. We report characteristics and outcomes of patients with blastoid/pleomorphic variants of MCL. We retrospectively studied adults with newly diagnosed MCL treated from 2000 to 2015. Primary objectives were to describe progression-free survival (PFS) and overall survival (OS). Secondary objectives included characterization of patient characteristics and treatments. Of the 1029 patients with MCL studied, a total of 207 neoplasms were blastoid or pleomorphic variants. Median follow-up period was 82 months (range, 0.1-174 months); median PFS was 38 months (95% confidence interval [CI], 28-66) and OS was 68 months (95% CI, 45-96). Factors associated with PFS were receipt of consolidative autologous hematopoietic transplantation (auto-HCT; hazard ratio [HR], 0.52; 95% CI, 0.31-0.80; P < .05), MCL International Prognostic Index (MIPI) intermediate (HR, 2.3; 95% CI, 1.2-4.3; P < .02) and high (HR, 3.8; 95% CI, 2.0-7.4; P < .01) scores, and complete response to induction (HR, 0.29 (95% CI, 0.17-0.51). Receipt of auto-HCT was not associated with OS (HR, 0.69; 95% CI, 0.41-1.16; P = .16) but was associated with MIPI intermediate (HR, 5.7; 95% CI, 2.5-13.2; P < .01) and high (HR, 10.8; 95% CI, 4.7-24.9; P < .01) scores. We report outcomes in a large cohort of patients with blastoid/pleomorphic variant MCL. For eligible patients, receipt of auto-HCT after induction was associated with improved PFS but not OS. Higher MIPI score and auto-HCT ineligibility were associated with worse survival.
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影响因子：
11.4
作者：
Bernard, M;Gressin, R;Lamy, T
通讯作者：
Lamy, T
DOI：
10.3324/haematol.2009.010264
发表时间：
2009-11-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Mozos, Ana;Royo, Cristina;Campo, Elias
通讯作者：
Campo, Elias
影响因子：
20.3
作者：
Dreyling, M;Lenz, G;Hiddemann, W
通讯作者：
Hiddemann, W
影响因子：
168.9
作者：
Mato, Anthony R.;Shah, Nirav N.;Wang, Michael
通讯作者：
Wang, Michael
影响因子：
2.6
作者：
Bhatt, Vijaya R.;Loberiza, Fausto R., Jr.;Bociek, R. Gregory
通讯作者：
Bociek, R. Gregory