Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma.
Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma.
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DOI：
10.1111/j.1749-6632.2008.03808.x
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发表时间：
2009-04
影响因子：
5.2
通讯作者：
Bennett RG
中科院分区：
文献类型：
--
作者：
Singh S;Bennett RG
Relaxin (Rlx) has antifibrotic effects in a number of tissues. Many of these effects are similar to those induced by the activators of peroxisome proliferator-activated receptor γ (PPARγ), raising the possibility that a mechanism for Rlx’s antifibrotic effects may involve activation of the PPARγ pathway. This study investigates the effect of Rlx on PPARs and their mechanism of upregulation. It shows that Rlx stimulates ligand-independent PPAR activation in a dose-dependent manner. The combined effect of Rlx and PPARγ agonists was superadditive, suggesting that both agents might be used together for an increased antifibrotic effect. Rlx caused increased expression of the PPARγ target genes CD36 and LXRα. Rlx’s effect was mimicked by forskolin, and partially blocked by pertussis toxin, suggesting that Rlx is working through a cAMP/PKA pathway to activate PPARγ. A better understanding of this pathway might help in the amelioration of fibrotic diseases.
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影响因子：
2.6
作者：
Qi, C;Zhu, YJ;Reddy, JK
通讯作者：
Reddy, JK
DOI：
10.1152/ajpgi.00124.2006
发表时间：
2006-11-01
影响因子：
4.5
作者：
Yang, Liu;Chan, Che-Chang;Rockey, Don C.
通讯作者：
Rockey, Don C.
影响因子：
64.8
作者：
Jiang, CY;Ting, AT;Seed, B
通讯作者：
Seed, B
影响因子：
64.8
作者：
Kersten, S;Desvergne, B;Wahli, W
通讯作者：
Wahli, W
影响因子：
56.9
作者：
Hsu, SY;Nakabayashi, K;Hsueh, AJW
通讯作者：
Hsueh, AJW