Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis.
Diagnostic accuracy of circulating tumor cells detection in gastric cancer: systematic review and meta-analysis.
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胃癌循环肿瘤细胞检测的诊断准确性：系统评价和荟萃分析
DOI：
10.1186/1471-2407-13-314
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发表时间：
2013-06-27
期刊：
影响因子：
3.8
通讯作者：
Zhong M
中科院分区：
文献类型：
--
作者：
Tang L;Zhao S;Liu W;Parchim NF;Huang J;Tang Y;Gan P;Zhong M
背景循环肿瘤细胞(CTCs)检测已被用于诊断胃癌。方法采用系统回顾和荟萃分析的方法，评价CTCs检测对胃癌诊断的总体准确性。PubMed、Embase和万方数据库以截至2012年10月出版的所有语言进行了检索。计算合并敏感度(SEN)、特异度(SPE)、阳性似然比(PLR)和阴性似然比(NLR)、诊断优势比(DOR)和总体受试者操作特征(SROC)曲线以评价总体测试效果。计算CTCs检测对胃癌的诊断价值，评价整体检测性能。合并估计的灵敏度、特异度、阳性和阴性似然比、诊断优势比分别为0.42(95%可信区间，0.21~0.67)、0.99(95%可信区间，0.96~1.00)、58.2(95%可信区间，9.8~345.9)、0.58(95%可信区间，0.38~0.89)和100(95%可信区间，15~663)。受试者操作特征曲线总和为0.97(95%CI，0.95~0.98)。Deek的漏斗图不对称性检验在本研究中没有发现研究发表偏倚的证据(P = 0.49)。结论这项系统性综述表明，单独检测CTCs不能被推荐作为胃癌的筛查试验。但可作为一种无创性检查方法，用于胃癌诊断的确证。
BackgroundCirculating tumor cells (CTCs) detection has previously been used for diagnosing gastric cancer. However, the previous studies failed to make an agreement whether the detection of CTCs contributes to the diagnosis of gastric cancer.MethodsA systematic review and meta-analysis was performed to evaluate the overall accuracy of CTCs detection for diagnosing gastric cancer. PubMed, Embase and the Wanfang database were searched in all languages published up to Oct 2012. The pooled sensitivity (SEN), specificity (SPE), positive and negative likelihood ratios (PLR and NLR, respectively), diagnostic odds ratio (DOR) and summary receiver operating characteristic (sROC) curve were calculated to evaluate the overall test performance.ResultsTwenty studies were included in this systematic review and meta-analysis. The diagnostic value of CTCs detection for the gastric cancer was calculated to evaluate the overall test performance. The summary estimates of The pooled sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio were 0.42 (95% confidence interval (CI), 0.21-0.67), 0.99 (95% CI, 0.96-1.00), 58.2 (95% CI, 9.8-345.9), 0.58 (95% CI, 0.38-0.89), and 100 (95% CI, 15–663), respectively. The summary receiver operating characteristic curve was 0.97 (95% CI, 0.95–0.98). Deek’s funnel plot asymmetry test found no evidence of study publication bias in the current study (P = 0.49).ConclusionThis systematic review suggests that CTCs detection alone cannot be recommended as a screening test for gastric cancer. However, it might be used as a noninvasive method for the confirmation of the gastric cancer diagnosis.
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DOI：
10.1093/jnci/88.9.590
发表时间：
1996-05-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Kunter, U;Buer, J;Atzpodien, J
通讯作者：
Atzpodien, J
影响因子：
9.3
作者：
Bossuyt, PM;Reitsma, JB;de Vet, HCW
通讯作者：
de Vet, HCW
影响因子：
6.7
作者：
Gerges, Noha;Rak, Janusz;Jabado, Nada
通讯作者：
Jabado, Nada
影响因子：
--
作者：
Deeks, JJ
通讯作者：
Deeks, JJ
DOI：
10.1016/s0140-6736(09)60617-6
发表时间：
2009-08-08
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hartgrink HH;Jansen EP;van Grieken NC;van de Velde CJ
通讯作者：
van de Velde CJ