Control of hyperoxaluria with large doses of pyridoxine in patients with kidney stones
Control of hyperoxaluria with large doses of pyridoxine in patients with kidney stones
复制标题
大剂量吡哆醇控制肾结石患者高草酸尿症
DOI：
10.1007/bf02549567
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发表时间：
1988
影响因子：
2
通讯作者：
D. Oreopoulos
中科院分区：
文献类型：
--
作者：
A. Mitwalli;A. Ayiomamitis;L. Grass;D. Oreopoulos
12例复发性草酸钙肾结石和特发性高草酸尿症患者口服吡哆醇250~500 mg/d。在长达18个月的治疗中，这种疗法显著减少了尿草酸的排泄(p<；0.025)。在此期间，8名患者没有表现出活动性结石病的证据；3名患者的旧结石略有增大(S)，1名患者形成了1枚新结石。这些患者中没有一人在治疗中出现任何明显的并发症。这些发现支持这样的观点，即药理剂量的吡哆醇在控制复发草酸结石患者尿草酸排泄增加方面是有用的。
Pyridoxine in doses of 250–500 mg daily by mouth was administered to 12 patients suffering from recurrent calcium oxalate renal calculi and idiopathic hyperoxaluria. This therapy decreased urinary oxalate excretion significantly (p<0.025) during up to 18 months of treatment. In that period eight patients showed no evidence of active stone disease; three showed slight increase in the size of their old stone(s) and one patient formed one new stone. None of these patients developed any significant complications of the therapy. These findings support the view that pyridoxine in pharmacological doses is useful in the control of elevated urinary oxalate excretion in patients with recurrent renal oxalate calculi.
影响因子：
158.5
作者：
SCHAUMBURG, H;KAPLAN, J;BROWN, MJ
通讯作者：
BROWN, MJ