Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.
Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.
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DOI：
10.1016/j.cmet.2014.04.018
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发表时间：
2014-07-01
期刊：
影响因子：
29
通讯作者：
de Cabo R
中科院分区：
文献类型：
--
作者：
Mattison JA;Wang M;Bernier M;Zhang J;Park SS;Maudsley S;An SS;Santhanam L;Martin B;Faulkner S;Morrell C;Baur JA;Peshkin L;Sosnowska D;Csiszar A;Herbert RL;Tilmont EM;Ungvari Z;Pearson KJ;Lakatta EG;de Cabo R
由慢性炎症环境驱动的中央动脉壁硬化伴随动脉疾病，是西方社会心血管（CV）发病率和死亡率的主要原因。中心动脉壁硬化增加（测量为主动脉脉搏波速度（PWV）增加）是临床CV疾病事件的主要风险因素。然而，目前还没有降低PWV的特异性疗法。在恒河猴中，为期两年的高脂肪和蔗糖饮食（HFS）不仅增加了体重和胆固醇，而且还诱导了显著的中央动脉壁硬化并增加了PWV和炎症。观察到的内皮细胞完整性丧失、脂质和巨噬细胞浸润以及动脉壁钙化是由氧化应激和炎症的基因组和蛋白质组特征驱动的。白藜芦醇可预防HFS诱导的动脉壁炎症和伴随的PWV增加。膳食白藜芦醇可能有望成为改善PWV增加的新疗法。
Central arterial wall stiffening driven by a chronic inflammatory milieu accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. Increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a two-year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation. The observed loss of endothelial cell integrity, lipid and macrophage infiltration, and calcification of the arterial wall were driven by genomic and proteomic signatures of oxidative stress and inflammation. Resveratrol prevented the HFS-induced arterial wall inflammation and the accompanying increase in PWV. Dietary resveratrol may hold promise as a novel therapy to ameliorate increases in PWV.
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影响因子：
3.3
作者：
Park SS;Wu WW;Zhou Y;Shen RF;Martin B;Maudsley S
通讯作者：
Maudsley S
影响因子：
24
作者：
Najjar, Samer S.;Scuteri, Angelo;Lakatta, Edward G.
通讯作者：
Lakatta, Edward G.
影响因子：
8.3
作者：
Carrizzo, Albino;Puca, Annibale;Vecchione, Carmine
通讯作者：
Vecchione, Carmine
影响因子：
7.7
作者：
Fiori JL;Shin YK;Kim W;Krzysik-Walker SM;González-Mariscal I;Carlson OD;Sanghvi M;Moaddel R;Farhang K;Gadkaree SK;Doyle ME;Pearson KJ;Mattison JA;de Cabo R;Egan JM
通讯作者：
Egan JM
影响因子：
39.3
作者：
Reference Values for Arterial Stiffness' Collaboration
通讯作者：
Reference Values for Arterial Stiffness' Collaboration