Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis.
Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis.
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比较转录组分析揭示了器官发生过程中脊椎动物的系统型时期。
DOI：
10.1038/ncomms1248
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发表时间：
2011
影响因子：
16.6
通讯作者：
Kuratani, Shigeru
中科院分区：
文献类型：
--
作者：
Irie, Naoki;Kuratani, Shigeru
进化发育生物学的核心问题之一是我们如何制定进化和发育过程之间的关系。两个主要的模型已经被提出：“漏斗状”模型，其中最早的胚胎显示出最保守的形态模式，其次是多样化的后期阶段，和“沙漏”模型，其中施加限制以保存器官发生阶段，这被称为异型期。在这里，我们对几种模式脊椎动物胚胎进行了定量比较转录组分析，结果表明咽期是最保守的，而早期和晚期则相当不同。这些结果使我们能够预测不同物种之间的近似发育时间表，并表明咽胚胎具有最保守的基因表达谱，这可能是脊椎动物基本身体计划的来源。物种间胚胎发育的保守性是进化生物学的重要内容。在这里，通过转录组分析，作者表明胚胎发育中期的咽部发育阶段在小鼠、鸡、青蛙和斑马鱼之间是保守的。
One of the central issues in evolutionary developmental biology is how we can formulate the relationships between evolutionary and developmental processes. Two major models have been proposed: the 'funnel-like' model, in which the earliest embryo shows the most conserved morphological pattern, followed by diversifying later stages, and the 'hourglass' model, in which constraints are imposed to conserve organogenesis stages, which is called the phylotypic period. Here we perform a quantitative comparative transcriptome analysis of several model vertebrate embryos and show that the pharyngula stage is most conserved, whereas earlier and later stages are rather divergent. These results allow us to predict approximate developmental timetables between different species, and indicate that pharyngula embryos have the most conserved gene expression profiles, which may be the source of the basic body plan of vertebrates. The conservation of embryonic development across species is of great interest in evolutionary biology. Here, using transcriptome analysis, the authors show that the pharyngula stage of development—in mid-embryogenesis—is conserved between mice, chickens, frogs and zebrafish.
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影响因子：
12.3
作者：
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者：
Zhang J
DOI：
10.1002/jez.b.21033
发表时间：
2005-03-15
影响因子：
2.2
作者：
Hazkani-Covo, E;Wool, D;Graur, D
通讯作者：
Graur, D
影响因子：
2.5
作者：
KIMMEL, CB;BALLARD, WW;SCHILLING, TF
通讯作者：
SCHILLING, TF
影响因子：
3.5
作者：
Kaneko, K;Yomo, T
通讯作者：
Yomo, T
DOI：
10.1098/rspb.2002.2242
发表时间：
2003-02-22
影响因子：
4.7
作者：
Bininda-Emonds, ORP;Jeffery, JE;Richardson, MK
通讯作者：
Richardson, MK