Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53.
Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53.
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DOI：
10.1016/j.ejca.2010.07.007
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发表时间：
2010-12
影响因子：
8.4
通讯作者：
Baek, Seung Joon
中科院分区：
文献类型：
--
作者：
Zhong, Yi;Krisanapun, Chuttuadee;Lee, Seong-Ho;Nualsanit, Thararat;Sams, Carl;Peungvicha, Penchom;Baek, Seung Joon
令人信服的流行病学和实验证据表明，膳食类黄酮具有抗癌活性。由于传统的治疗和手术方法已经不能完全控制大多数癌症类型的发病率和结果，包括结直肠肿瘤，迫切需要开发用于癌症管理的替代方法。我们试图开发最好的黄酮类化合物抑制细胞生长，芹菜素（黄酮）被证明是最有前途的化合物在结直肠癌细胞生长停滞。随后，我们发现，在芹菜素的存在下，促凋亡蛋白（NAG-1和p53）和细胞周期抑制因子（p21）被诱导，激酶途径，包括PKCδ和共济失调毛细血管扩张突变（ATM），在激活这些蛋白质中发挥重要作用。体外实验产生的数据在使用APCMIN+小鼠的动物研究中得到证实。芹菜素能够减少息肉的数量，同时通过动物模型中的磷酸化增加p53的活化。我们的数据表明芹菜素对结肠癌有明显的有益作用。
Persuasive epidemiological and experimental evidence suggests that dietary flavonoids have anti-cancer activity. Since conventional therapeutic and surgical approaches have not been able to fully control the incidence and outcome of most cancer types, including colorectal neoplasia, there is an urgent need to develop alternative approaches for the management of cancer. We sought to develop the best flavonoids for the inhibition of cell growth, and apigenin (flavone) proved the most promising compound in colorectal cancer cell growth arrest. Subsequently, we found that pro-apoptotic proteins (NAG-1 and p53) and cell cycle inhibitor (p21) were induced in the presence of apigenin, and kinase pathways, including PKCδ and ataxia telangiectasia mutated (ATM), play an important role in activating these proteins. The data generated by in vitro experiments were confirmed in an animal study using APCMIN+ mice. Apigenin is able to reduce polyp numbers, accompanied by increasing p53 activation through phosphorylation in animal models. Our data suggest apparent beneficial effects of apigenin on colon cancer.
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影响因子：
5.4
作者：
Pise-Masison, CA;Radonovich, M;Brady, JN
通讯作者：
Brady, JN
影响因子：
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影响因子：
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作者：
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通讯作者：
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