The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis.
The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis.
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DOI：
10.5483/bmbrep.2008.41.12.833
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发表时间：
2008-12-31
期刊：
影响因子：
3.8
通讯作者：
McDonald DM
中科院分区：
文献类型：
--
作者：
You WK;McDonald DM
肿瘤中的血管生成是由激活受体酪氨酸激酶的多种生长因子驱动的。实体瘤血管生成的重要驱动力是通过血管内皮生长因子（VEGF）及其受体（VEGFRs）发出信号。针对这一信号通路的血管生成抑制剂现在被广泛用于癌症的治疗。然而，当单独使用时，VEGF/VEGFR信号抑制剂不会破坏肿瘤中的所有血管，也不会减缓大多数人类癌症的生长。因此，VEGF/VEGFR信号抑制剂与化疗药物或放射治疗联合使用。其他抑制血管生成的靶点将有助于更有效地治疗癌症。一个有希望的靶点是肝细胞生长因子（HGF）及其受体（HGFR，也称为c-Met）的信号通路，它在血管生成和肿瘤生长中起着重要作用。该信号通路的抑制剂已在多种体外和体内模型中被证明可以抑制血管生成。HGF/c-Met信号通路目前被认为是抑制血管生成、肿瘤生长、侵袭和转移的一个有希望的靶点。
Angiogenesis in tumors is driven by multiple growth factors that activate receptor tyrosine kinases. An important driving force of angiogenesis in solid tumors is signaling through vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). Angiogenesis inhibitors that target this signaling pathway are now in widespread use for the treatment of cancer. However, when used alone, inhibitors of VEGF/VEGFR signaling do not destroy all blood vessels in tumors and do not slow the growth of most human cancers. VEGF/VEGFR signaling inhibitors are, therefore, used in combination with chemotherapeutic agents or radiation therapy. Additional targets for inhibiting angiogenesis would be useful for more efficacious treatment of cancer. One promising target is the signaling pathway of hepatocyte growth factor (HGF) and its receptor (HGFR, also known as c-Met), which plays important roles in angiogenesis and tumor growth. Inhibitors of this signaling pathway have been shown to inhibit angiogenesis in multiple in vitro and in vivo models. The HGF/c-Met signaling pathway is now recognized as a promising target in cancer by inhibiting angiogenesis, tumor growth, invasion, and metastasis.
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