Does obesity attenuate the effect of metabolic syndrome on chronic kidney disease in patients with coronary artery disease? Report from China heart survey.
Does obesity attenuate the effect of metabolic syndrome on chronic kidney disease in patients with coronary artery disease? Report from China heart survey.
复制标题
肥胖是否会减弱代谢综合征对冠心病患者慢性肾脏病的影响？
作者：
Hao Liu;Jinming Yu;Fang Chen;Jinsong Wang;Shengbao Chen;Fang Wang;D. Hu
背景
本研究探讨了中国冠状动脉疾病（CAD）患者代谢综合征（MetS）与慢性肾脏病（CKD）之间的关系。
方法和结果
2005年6月1日至8月31日，对中国心脏调查中3,465名患有CAD的参与者进行了MetS和CKD的患病率测定，并分析了MetS和CKD之间的关系。 MetS 和 CKD 的患病率分别为 53.0% 和 21.1%。患有 MetS 的患者比没有 MetS 的患者有更高的 CKD 患病率。除中心性肥胖外，MetS 的所有性状均与 CKD 具有统计学显着相关性。有或没有 MetS 的参与者的 CKD 多变量调整比值比 (OR) 为 1.27（95% 置信区间 (CI) 1.07-1.51）。在多变量调整模型中，具有 3 个 MetS 成分（不包括向心性肥胖）的患者 CKD 的 OR 较高（OR 2.17，95% CI 1.21-3.88）。
结论
MetS 是 CAD 患者发生 CKD 的一个显着较高的危险因素。无论 MetS 成分的数量如何，向心性肥胖可能会减弱 CKD 患者中 MetS 对 CKD 的影响。
BACKGROUND
The present study explored the relationship between metabolic syndrome (MetS) and chronic kidney disease (CKD) in patients with coronary artery disease (CAD) in China.
METHODS AND RESULTS
The prevalence of MetS and CKD were determined in 3,465 participants with CAD from the China Heart Survey, from June 1(st) to August 31(st) 2005. The relationship between MetS and CKD was analyzed. The prevalence of MetS and CKD was 53.0% and 21.1%, respectively. Patients with MetS had a higher prevalence of CKD than those without MetS. All traits of MetS except central obesity were statistically significantly associated with CKD. The multivariate-adjusted odds ratio (OR) of CKD in participants with and without MetS was 1.27 (95% confidence interval (CI) 1.07-1.51). In the multivariate-adjusted model, patients with 3 MetS components, excluding central obesity, had a higher OR for CKD (OR 2.17, 95%CI 1.21-3.88).
CONCLUSIONS
MetS is a significantly higher risk factor for CKD in patients with CAD. Central obesity might attenuate the effect of MetS on CKD in patients with CKD, regardless of the number of MetS components.
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影响因子：
39.3
作者：
Romero-Corral, Abel;Somers, Virend K.;Lopez-Jimenez, Francisco
通讯作者：
Lopez-Jimenez, Francisco
DOI：
10.2215/cjn.04231206
发表时间：
2007-05-01
影响因子：
9.8
作者：
Kestenbaum, Bryan;Rudser, Kyle D.;Siscovick, David S.
通讯作者：
Siscovick, David S.
DOI：
10.1097/01.asn.0000046029.53933.09
发表时间：
2003-02-01
影响因子：
13.6
作者：
Chen, J;Muntner, P;He, J
通讯作者：
He, J
影响因子：
6.1
作者：
Chen, Jing;Gu, Dongfeng;He, Jiang
通讯作者：
He, Jiang
影响因子：
7.1
作者：
Janssen, I;Heymsfield, SB;Ross, R
通讯作者：
Ross, R