Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood.
Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood.
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DOI：
10.1016/j.biopsych.2011.03.035
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发表时间：
2011-09-15
影响因子：
10.6
通讯作者：
Konradi, Christine
中科院分区：
文献类型：
--
作者：
Daws, Stephanie E.;Black, Yolanda D.;Naydenov, Alipi V.;Vassoler, Fair R.;Hanlin, Ryan P.;Konradi, Christine
在青少年时期服用可卡因会改变成年期的神经传递和行为敏化，但其对恐惧记忆的获得和基于情绪的神经回路的发展的影响尚不清楚。我们研究了在青春期接受大量可卡因治疗的成年雄性大鼠的恐惧学习和焦虑相关行为。在最后一次注射可卡因22小时后，我们进一步对杏仁核进行了基因表达分析，以确定可能导致情绪处理改变的分子模式。在青春期注射可卡因的大鼠在成年后表现出的焦虑程度要低于注射毒品的大鼠。此外，暴露于可卡因的动物缺乏产生情境恐惧反应的能力。可卡因引起Wnt信号通路、轴突引导分子和突触蛋白基因表达的短暂改变，表明可卡因扰乱了杏仁核的树突结构和突触。糖原合成酶激酶3 β （Wnt信号通路中的一种激酶）的磷酸化在暴吸可卡因后立即发生改变，并在最后一次可卡因注射后22小时恢复到正常水平。青少年时期的可卡因暴露会导致杏仁核的分子变化，减少成年期的恐惧学习和恐惧反应。
Administration of cocaine during adolescence alters neurotransmission and behavioral sensitization in adulthood, but its effect on the acquisition of fear memories and the development of emotion-based neuronal circuits is unknown. We examined fear learning and anxiety-related behaviors in adult male rats that were subjected to binge cocaine treatment during adolescence. We furthermore conducted gene expression analyses of the amygdala 22 hours after the last cocaine injection to identify molecular patterns that might lead to altered emotional processing. Rats injected with cocaine during adolescence displayed less anxiety in adulthood than their vehicle-injected counterparts. In addition, cocaine-exposed animals were deficient in their ability to develop contextual fear responses. Cocaine administration caused transient gene expression changes in the Wnt signaling pathway, of axon guidance molecules, and of synaptic proteins, suggesting that cocaine perturbs dendritic structures and synapses in the amygdala. Phosphorylation of glycogen synthase kinase 3 beta, a kinase in the Wnt signaling pathway, was altered immediately following the binge cocaine paradigm and returned to normal levels 22 hours after the last cocaine injection. Cocaine exposure during adolescence leads to molecular changes in the amygdala and decreases fear learning and fear responses in adulthood.
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DOI：
10.1073/pnas.011404098
发表时间：
2001-01-02
影响因子：
11.1
作者：
Li, C;Wong, WH
通讯作者：
Wong, WH
影响因子：
5.7
作者：
Chen SY;Cheng HJ
通讯作者：
Cheng HJ
DOI：
10.1509/jmkr.46.3.384
发表时间：
2009-06-01
期刊：
JMR, Journal of marketing research
影响因子：
--
作者：
Griskevicius V;Goldstein NJ;Mortensen CR;Sundie JM;Cialdini RB;Kenrick DT
通讯作者：
Kenrick DT
影响因子：
10.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ
DOI：
10.1111/j.1460-9568.2009.06888.x
发表时间：
2009-09
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Fuchs RA;Bell GH;Ramirez DR;Eaddy JL;Su ZI
通讯作者：
Su ZI