Recombination rates and genomic shuffling in human and chimpanzee--a new twist in the chromosomal speciation theory.
Recombination rates and genomic shuffling in human and chimpanzee--a new twist in the chromosomal speciation theory.
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DOI：
10.1093/molbev/mss272
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发表时间：
2013-04
影响因子：
10.7
通讯作者：
Ruiz-Herrera A
中科院分区：
文献类型：
--
作者：
Farré M;Micheletti D;Ruiz-Herrera A
进化生物学中一个长期存在的问题是重组在塑造生物体基因组结构中的作用，特别是这如何影响物种形成过程。尽管在过去的十年中，染色体重组在人类-黑猩猩物种形成过程中的作用仍然没有得到解决。通过全基因组比较，我们分析了在人类-黑猩猩物种形成过程中，基因组改组对人类重组率分布的全基因组影响。我们已经构建了一个高度精细的地图重组和进化断点区域在人类和黑猩猩基因组的基础上的orthopathic基因和基因组序列比对。从全基因组单核苷酸多态性数据推断的最新人类和黑猩猩重组图的分析显示，重排染色体的标准化重组率显着低于共线染色体。事实上，重排后的染色体的重组率明显低于自类人猿祖先以来一直保持的染色体，这与它们固定的谱系有关。重要的是，倒置区域有较低的重组率比共线和noninverted地区，独立的着丝粒的影响。我们的观察结果对染色体物种形成理论有一定的意义，为倒位在哺乳动物中抑制重组的贡献提供了新的证据。
A long-standing question in evolutionary biology concerns the effect of recombination in shaping the genomic architecture of organisms and, in particular, how this impacts the speciation process. Despite efforts employed in the last decade, the role of chromosomal reorganizations in the human–chimpanzee speciation process remains unresolved. Through whole-genome comparisons, we have analyzed the genome-wide impact of genomic shuffling in the distribution of human recombination rates during the human–chimpanzee speciation process. We have constructed a highly refined map of the reorganizations and evolutionary breakpoint regions in the human and chimpanzee genomes based on orthologous genes and genome sequence alignments. The analysis of the most recent human and chimpanzee recombination maps inferred from genome-wide single-nucleotide polymorphism data revealed that the standardized recombination rate was significantly lower in rearranged than in collinear chromosomes. In fact, rearranged chromosomes presented significantly lower recombination rates than chromosomes that have been maintained since the ancestor of great apes, and this was related with the lineage in which they become fixed. Importantly, inverted regions had lower recombination rates than collinear and noninverted regions, independently of the effect of centromeres. Our observations have implications for the chromosomal speciation theory, providing new evidences for the contribution of inversions in suppressing recombination in mammals.
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DOI：
10.1093/bioinformatics/btr064
发表时间：
2011-04-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Grant CE;Bailey TL;Noble WS
通讯作者：
Noble WS
影响因子：
4.5
作者：
Feuk L;MacDonald JR;Tang T;Carson AR;Li M;Rao G;Khaja R;Scherer SW
通讯作者：
Scherer SW
影响因子：
7
作者：
Bullaughey, Kevin;Przeworski, Molly;Coop, Graham
通讯作者：
Coop, Graham
影响因子：
4.5
作者：
Carbone L;Harris RA;Vessere GM;Mootnick AR;Humphray S;Rogers J;Kim SK;Wall JD;Martin D;Jurka J;Milosavljevic A;de Jong PJ
通讯作者：
de Jong PJ
影响因子：
5.8
作者：
Baudet, Christian;Lemaitre, Claire;Sagot, Marie-France
通讯作者：
Sagot, Marie-France