SARS-CoV-2 in Domestic UK Cats from Alpha to Omicron: Swab Surveillance and Case Reports.
SARS-CoV-2 in Domestic UK Cats from Alpha to Omicron: Swab Surveillance and Case Reports.
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DOI：
10.3390/v15081769
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发表时间：
2023-08-19
期刊：
影响因子：
--
通讯作者：
Hosie MJ
中科院分区：
文献类型：
--
作者：
Jones S;Tyson GB;Orton RJ;Smollett K;Manna F;Kwok K;Suárez NM;Logan N;McDonald M;Bowie A;Filipe ADS;Willett BJ;Weir W;Hosie MJ
虽然家猫容易感染SARS-CoV-2，但该病毒在引起猫科动物疾病中的作用尚不清楚。我们进行了一项大规模研究，通过主动和被动监测来识别英国宠物猫的SARS-CoV-2感染。使用RT-qPCR对2021年5月至2023年2月期间提交用于其他病原体检测的残留猫呼吸道拭子样本进行筛查。此外，我们呼吁兽医从疑似临床SARS-CoV-2感染的猫身上采集拭子样本。还应要求对疑似病例进行了SARS-CoV-2中和抗体的定制检测。在Delta波期间（1/175，0.57%），通过主动监测（1/549，0.18%）识别出1只RT-qPCR阳性猫。被动监测检测到一只猫感染了α变体，十只猫中有两只在Delta波期间检测到RT-qPCR阳性。在Omicron BA.1及其后代出现后，没有猫检测到RT-qPCR阳性，尽管374只猫通过主动监测检测，11只猫通过被动监测检测。我们描述了四例宠物猫的SARS-CoV-2感染，通过RT-qPCR和/或血清学鉴定，表现出一系列临床体征，以及它们的SARS-CoV-2基因组序列。这些病例表明，虽然在猫中不常见，但可能发生各种临床体征。
Although domestic cats are susceptible to infection with SARS-CoV-2, the role of the virus in causing feline disease is less well defined. We conducted a large-scale study to identify SARS-CoV-2 infections in UK pet cats, using active and passive surveillance. Remnant feline respiratory swab samples, submitted for other pathogen testing between May 2021 and February 2023, were screened using RT-qPCR. In addition, we appealed to veterinarians for swab samples from cats suspected of having clinical SARS-CoV-2 infections. Bespoke testing for SARS-CoV-2 neutralising antibodies was also performed, on request, in suspected cases. One RT-qPCR-positive cat was identified by active surveillance (1/549, 0.18%), during the Delta wave (1/175, 0.57%). Passive surveillance detected one cat infected with the Alpha variant, and two of ten cats tested RT-qPCR-positive during the Delta wave. No cats tested RT-qPCR-positive after the emergence of Omicron BA.1 and its descendants although 374 were tested by active and eleven by passive surveillance. We describe four cases of SARS-CoV-2 infection in pet cats, identified by RT-qPCR and/or serology, that presented with a range of clinical signs, as well as their SARS-CoV-2 genome sequences. These cases demonstrate that, although uncommon in cats, a variety of clinical signs can occur.
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