Targeted mechanical forces enhance the effects of tumor immunotherapy by regulating immune cells in the tumor microenvironment.
Targeted mechanical forces enhance the effects of tumor immunotherapy by regulating immune cells in the tumor microenvironment.
复制标题
靶向机械力通过调节肿瘤微环境中的免疫细胞增强肿瘤免疫治疗的效果
DOI：
10.20892/j.issn.2095-3941.2022.0491
复制
发表时间：
2023-01-12
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
肿瘤微环境中的机械力(TME)与肿瘤的生长、增殖和耐药性有关。肿瘤中强大的机械力改变了癌细胞的代谢和行为，从而促进了肿瘤的进展和转移。机械信号被转化为生化信号，生化信号通过机械转导激活致癌信号通路。癌症免疫治疗最近取得了令人振奋的进展，开启了一个“无化疗”治疗的新时代。然而，由于肿瘤微环境的复杂性，免疫治疗在多种肿瘤治疗中并未取得令人满意的效果。在这里，我们讨论机械力对肿瘤免疫微环境的影响，并强调在免疫治疗中针对机械力的新的治疗策略。
Mechanical forces in the tumor microenvironment (TME) are associated with tumor growth, proliferation, and drug resistance. Strong mechanical forces in tumors alter the metabolism and behavior of cancer cells, thus promoting tumor progression and metastasis. Mechanical signals are transformed into biochemical signals, which activate tumorigenic signaling pathways through mechanical transduction. Cancer immunotherapy has recently made exciting progress, ushering in a new era of “chemo-free” treatments. However, immunotherapy has not achieved satisfactory results in a variety of tumors, because of the complex tumor microenvironment. Herein, we discuss the effects of mechanical forces on the tumor immune microenvironment and highlight emerging therapeutic strategies for targeting mechanical forces in immunotherapy.
DOI：
10.5114/ceji.2015.50841
发表时间：
2015
期刊：
Central-European journal of immunology
影响因子：
--
作者：
Osmola-Mańkowska A;Teresiak-Mikołajczak E;Dańczak-Pazdrowska A;Kowalczyk M;Żaba R;Adamski Z
通讯作者：
Adamski Z