The role of dendritic cells and regulatory T cells in the pathogenesis of morphea.
The role of dendritic cells and regulatory T cells in the pathogenesis of morphea.
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DOI：
10.5114/ceji.2015.50841
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Adamski Z
中科院分区：
文献类型：
--
作者：
Osmola-Mańkowska A;Teresiak-Mikołajczak E;Dańczak-Pazdrowska A;Kowalczyk M;Żaba R;Adamski Z
睡眠病是一种以皮肤和皮下组织纤维化为特征的疾病。它是一种慢性疾病，不会缩短患者的生命，但会显著影响其质量。认为导致其发病机制的一组因素包括内皮细胞功能紊乱以及导致慢性炎性病症的免疫紊乱，伴随着胶原蛋白和其他细胞外基质组分的产生增加。树突状细胞（DC）是一种专职的抗原提呈细胞，几乎可以在所有的身体组织中发现。个体研究已经证明在形态学皮肤病变中、在更深的真皮层内、在血管周围和在皮下组织中的胶原纤维周围存在大量的浆细胞样DC（pDC）。与系统性硬化症（SSc）相比，DC似乎在硬斑病的炎症和T细胞活化的发展中具有更显著的作用。调节性T（Treg）细胞代表具有免疫抑制特性的T细胞亚群。最近的研究引起了人们对Treg在自身免疫过程中所起的重要作用的关注。只有少数研究表明SSc患者Treg的数量和活性降低，并且只有这些研究涉及硬斑病。本文就DC和调节性T细胞在硬斑病发病机制中的作用作一综述。此外，光疗的机制和潜在的治疗目标在治疗硬斑病的讨论。
Morphea is one of diseases characterised by fibrosis of the skin and subcutaneous tissue. It is a chronic disease that does not shorten the life of the patient, yet significantly affects its quality. The group of factors responsible for its pathogenesis is thought to include disturbed functioning of endothelial cells as well as immune disturbances leading to chronic inflammatory conditions, accompanied by increased production of collagen and of other extracellular matrix components. Dendritic cells (DC) are a type of professional antigen-presenting cells and can be found in almost all body tissues. Individual investigations have demonstrated high numbers of plasmacytoid DC (pDC) in morphoeic skin lesions, within deeper dermal layers, around blood vessels, and around collagen fibres in subcutaneous tissue. It appears that DC has a more pronounced role in the development of inflammation and T cell activation in morphea, as compared to systemic sclerosis (SSc). Regulatory T (Treg) cells represent a subpopulation of T cells with immunosuppressive properties. Recent studies have drawn attention to the important role played by Treg in the process of autoimmunisation. Just a few studies have demonstrated a decrease in the number and activity of Treg in patients with SSc, and only such studies involve morphea. This article reviews recent studies on the role of DC and regulatory T cells in the pathogenesis of morphea. Moreover, mechanisms of phototherapy and potential therapeutic targets in the treatment of morphea are discussed in this context.
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