Structural Plasticity of the Primary and Secondary Olfactory cortices: Increased Gray Matter Volume Following Surgical Treatment for Chronic Rhinosinusitis
Structural Plasticity of the Primary and Secondary Olfactory cortices: Increased Gray Matter Volume Following Surgical Treatment for Chronic Rhinosinusitis
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初级和次级嗅皮质的结构可塑性：慢性鼻窦炎手术治疗后灰质体积增加
DOI：
10.1016/j.neuroscience.2018.10.011
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发表时间：
2018
期刊：
影响因子：
3.3
通讯作者：
Hummel T
中科院分区：
文献类型：
--
作者：
Whitcroft KL;Fischer J;Raue C;Bensafi M;Gudziol V;Andrews P;Hummel T
成年人大脑的功能可塑性已经得到很好的证实。最近，这种可塑性的结构对应已被神经影像学研究表明，经验依赖性差异的灰质（GM）的体积。在初级和次级嗅觉皮质内，已经证明嗅觉丧失患者的GM体积减少。然而，这些横截面的研究并没有提供因果关系的证据GM体积变化，从而结构的可塑性。外周嗅觉系统的疾病，如慢性鼻窦炎（CRS），提供了一个理想的模型来研究GM结构可塑性，因为患者可能会经历长时间的嗅觉障碍，然后通过治疗接近完全恢复。因此，我们在接受CRS手术治疗的患者中进行了一项前瞻性纵向研究。12例患者（男：女= 7：5;年龄47.2 ± 14.9岁），术后3个月，采用基于体素的形态测量法（VBM）研究GM体积变化。我们进行了逐体素的感兴趣区域分析，并对区域数量进行了显著性校正（p< 0.0036corr）。我们发现术后初级（左侧梨状皮质，右侧杏仁核）和次级（右侧眶额皮质，尾状核，海马-海马旁复合体和双侧颞极）嗅觉网络内的GM体积显著增加，而次级网络内的GM体积仅减少（左侧尾状核和颞极，双侧海马-海马旁复合体）。作为对照测量，我们评估了V1、S1和A1内的GM变化，其中没有阈上体素。据我们所知，这是第一个研究表明，在初级和次级嗅觉皮层的GM结构可塑性，嗅觉恢复。
Functional plasticity of the adult brain is well established. Recently, the structural counterpart to such plasticity has been suggested by neuroimaging studies showing experience-dependent differences in gray matter (GM) volumes. Within the primary and secondary olfactory cortices, reduced GM volumes have been demonstrated in patients with olfactory loss. However, these cross-sectional studies do not provide causal evidence for GM volume change, and thereby structural plasticity. Disorders of the peripheral olfactory system, such as chronic rhinosinusitis (CRS), provide an ideal model to study GM structural plasticity, given that patients may experience long periods of olfactory impairment, followed by near complete recovery with treatment. We therefore performed a prospective longitudinal study in patients undergoing surgical treatment for CRS. We used voxel-based morphometry (VBM) to investigate GM volume change in 12 patients (M:F = 7:5; 47.2 ± 14.9 years), 3 months post-op. There was a significant improvement in olfactory function according to birhinal psychophysical testing. We performed a voxel-wise region of interest analysis, with significance corrected for number of regions (p< 0.0036corr). We found significantly increased post-operative GM volumes within the primary (left piriform cortex, right amygdala) and secondary (right orbitofrontal cortex, caudate nucleus, hippocampal–parahippocampal complex and bilateral temporal poles) olfactory networks, and decreased GM volumes within the secondary network only (left caudate nucleus and temporal pole, bilateral hippocampal–parahippocampal complex). As a control measure, we assessed GM change within V1, S1 and A1, where there were no suprathreshold voxels. To our knowledge, this is the first study to demonstrate GM structural plasticity within the primary and secondary olfactory cortices, following restoration of olfaction.
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影响因子：
7.2
作者：
Delank Kw;W. Stoll
通讯作者：
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DOI：
10.1080/13803391003683070
发表时间：
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影响因子：
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影响因子：
3.3
作者：
K. Whitcroft;K. Whitcroft;K. Whitcroft;M. Aziz;Ilona Croy;Valentin A. Schriever;Thomas Hummel
通讯作者：
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影响因子：
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作者：
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