Neural correlates of moral and non-moral emotion in female psychopathy.
Neural correlates of moral and non-moral emotion in female psychopathy.
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DOI：
10.3389/fnhum.2014.00741
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发表时间：
2014
影响因子：
2.9
通讯作者：
Kiehl KA
中科院分区：
文献类型：
--
作者：
Harenski CL;Edwards BG;Harenski KA;Kiehl KA
这项研究首次对女性精神病患者进行了神经影像学调查。先前的研究发现，男性精神病患者在处理情绪刺激和做出道德判断时，与边缘系统和边缘系统激活减少有关。这项研究的目的是调查这些发现是否适用于女性精神病患者。在fMRI扫描过程中，157名被监禁和46名非监禁女性参与者观看了令人不快的图片，其中一半描绘了道德违规，以及中性图片。参与者对每一张照片的道德违规严重程度进行了评级。精神病评估使用精神病检查表修订版（PCL-R）在所有被监禁的参与者。非监禁的参与者被列为对照组，以获得与观看不愉快与中性图片（情感对比），以及描绘道德违规的不愉快图片与没有道德违规的不愉快图片（道德对比）相关的大脑区域。对被监禁组的回归分析研究了PCL-R分数与情绪和道德对比中大脑激活之间的关联。情绪对比结果显示，PCL-R得分与右侧杏仁核和前扣带回吻侧的激活呈负相关。道德对比的结果显示，PCL-R评分与右侧颞顶叶交界处的激活呈负相关。这些结果表明，女性精神病患者，像男性精神病患者一样，其特点是减少边缘激活情绪处理。相比之下，减少颞顶叶激活道德越轨已较少观察到男性精神病。这些结果扩展了先前在男性精神病女性精神病的研究结果，并揭示了异常的神经反应的道德显着的刺激，可能是独特的女性精神病。
This study presents the first neuroimaging investigation of female psychopathy in an incarcerated population. Prior studies have found that male psychopathy is associated with reduced limbic and paralimbic activation when processing emotional stimuli and making moral judgments. The goal of this study was to investigate whether these findings extend to female psychopathy. During fMRI scanning, 157 incarcerated and 46 non-incarcerated female participants viewed unpleasant pictures, half which depicted moral transgressions, and neutral pictures. Participants rated each picture on moral transgression severity. Psychopathy was assessed using the Psychopathy Checklist-Revised (PCL-R) in all incarcerated participants. Non-incarcerated participants were included as a control group to derive brain regions of interest associated with viewing unpleasant vs. neutral pictures (emotion contrast), and unpleasant pictures depicting moral transgressions vs. unpleasant pictures without moral transgressions (moral contrast). Regression analyses in the incarcerated group examined the association between PCL-R scores and brain activation in the emotion and moral contrasts. Results of the emotion contrast revealed a negative correlation between PCL-R scores and activation in the right amygdala and rostral anterior cingulate. Results of the moral contrast revealed a negative correlation between PCL-R scores and activation in the right temporo-parietal junction. These results indicate that female psychopathy, like male psychopathy, is characterized by reduced limbic activation during emotion processing. In contrast, reduced temporo-parietal activation to moral transgressions has been less observed in male psychopathy. These results extend prior findings in male psychopathy to female psychopathy, and reveal aberrant neural responses to morally-salient stimuli that may be unique to female psychopathy.
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影响因子：
4.6
作者：
Ermer, Elsa;Cope, Lora M.;Nyalakanti, Prashanth K.;Calhoun, Vince D.;Kiehl, Kent A.
通讯作者：
Kiehl, Kent A.
影响因子：
2
作者：
Decety J;Skelly L;Yoder KJ;Kiehl KA
通讯作者：
Kiehl KA
影响因子：
4.2
作者：
Cima, Maaike;Tonnaer, Franca;Hauser, Marc D.
通讯作者：
Hauser, Marc D.
影响因子：
4.6
作者：
Bagley, Amy D.;Abramowitz, Carolyn S.;Kosson, David S.
通讯作者：
Kosson, David S.
影响因子：
4.2
作者：
Harenski, Carla L.;Antonenko, Olga;Kiehl, Kent A.
通讯作者：
Kiehl, Kent A.