Viral etiology of severe pneumonia among Kenyan infants and children.
Viral etiology of severe pneumonia among Kenyan infants and children.
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DOI：
10.1001/jama.2010.675
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发表时间：
2010-05-26
影响因子：
120.7
通讯作者：
Nokes, D. James
中科院分区：
文献类型：
--
作者：
Berkley, James A.;Munywoki, Patrick;Ngama, Mwanajuma;Kazungu, Sidi;Abwao, John;Bett, Anne;Lassauniere, Ria;Kresfelder, Tina;Cane, Patricia A.;Venter, Marietjie;Scott, J. Anthony G.;Nokes, D. James
肺炎是撒哈拉以南非洲儿童死亡的主要原因。对致病病原体对疾病负担的贡献进行比较性估计对于靶向疫苗的开发至关重要。使用全面和敏感的分子诊断技术确定肯尼亚农村医院婴儿和儿童重症肺炎的病毒病原学。2007年在肯尼亚农村地区医院进行的前瞻性观察和病例对照研究。我们招募了居住在系统列举的集水区的1天至12岁的儿童：i）符合WHO“重症肺炎”或“极重症肺炎”临床标准的Kilifi地区医院收治的儿童; ii）出现轻度上呼吸道感染但未入院的儿童; iii）接受免疫接种的健康婴儿和儿童。呼吸道病毒的存在和重症入院的优势比。对759/922（83%）符合条件的入院者进行了抽样（中位年龄9个月）。在425/759例患者中检测到一种或多种呼吸道病毒（56%，95% CI 52 - 60%）。其中260例检出呼吸道合胞病毒（RSV）（34%，95% CI 31 - 38%）和其他呼吸道病毒，（29%，95% CI 26 - 32%），最常见的是人类冠状病毒229 E（n=51，6.7%，95% CI 5.0 - 8.7%），甲型流感（n=44，5.8%，95% CI 4.2 - 7.7%），3型副流感病毒（n=29，3.8%，95%CI 2.6至5.4%）、腺病毒（n=29，3.8%，95%CI 2.6至5.4%）和人偏肺病毒（n=23，3.0%，95%CI 1.9至4.5%）。与良好对照相比，RSV的检测与重度疾病相关（对照组中4%，校正比值比6.11 [95% CI 1.65 - 22.6]），而总体而言，其他呼吸道病毒与重度疾病无关（对照组中23%，校正比值比1.27 [95% CI 0.64 - 2.52]）。在肯尼亚一家乡村医院收治的重症肺炎婴儿和儿童样本中，RSV是主要的病毒病原体。
Pneumonia is the leading cause of childhood death in sub-Saharan Africa. Comparative estimates of the contribution of causative pathogens to the burden of disease are essential for targeted vaccine development. To determine the viral etiology of severe pneumonia among infants and children at a rural Kenyan hospital using comprehensive and sensitive molecular diagnostic techniques. Prospective observational and case control study during 2007 in a rural Kenyan district hospital. We recruited children age 1 day to 12 years who were resident in a systematically enumerated catchment area: i) those admitted to Kilifi District Hospital meeting WHO clinical criteria for ‘severe pneumonia’ or ‘very severe pneumonia’; ii) those presenting with mild upper respiratory tract infection but not admitted and iii) well infants and children attending for immunization. The presence of respiratory viruses and the odds ratio for admission with severe disease. 759/922 (83%) eligible admissions were sampled (median age 9 months). One or more respiratory viruses were detected in 425/759 (56%, 95% CI 52 to 60%). Respiratory syncytial virus (RSV) was detected in 260 (34%, 95% CI 31 to 38%) and other respiratory viruses in 219 (29%, 95% CI 26 to 32%), the commonest being human coronavirus 229E (n=51, 6.7%, 95% CI 5.0 to 8.7%), influenza type A (n=44, 5.8%, 95% CI 4.2 to 7.7%), parainfluenza type 3 (n=29, 3.8%, 95% CI 2.6 to 5.4%), adenovirus (n=29, 3.8%, 95% CI 2.6 to 5.4%) and human metapneumovirus (n=23, 3.0%, 95% CI 1.9 to 4.5%). Compared to well controls, detection of RSV was associated with severe disease (4% in controls, adjusted odds Ratio 6.11 [95% CI 1.65 to 22.6]) whilst collectively, other respiratory viruses were not (23% in controls, adjusted odds Ratio 1.27 [95% CI 0.64 to 2.52]). In a sample of Kenyan infants and children admitted with severe pneumonia to a rural hospital, RSV was the predominant viral pathogen.
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影响因子：
4.5
作者：
Ndiritu, Moses;Cowgill, Karen D.;Ismail, Amina;Chiphatsi, Salome;Kamau, Tatu;Fegan, Gregory;Feikin, Daniel R.;Newton, Charles R. J. C.;Scott, J. Anthony G.
通讯作者：
Scott, J. Anthony G.
DOI：
10.1016/j.jcv.2004.03.018
发表时间：
2004-10
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Kuypers J;Wright N;Morrow R
通讯作者：
Morrow R
影响因子：
5.4
作者：
Schmidt, AC;McAuliffe, JM;Collins, PL
通讯作者：
Collins, PL
影响因子：
168.9
作者：
Cutts, FT;Zaman, SMA;Adegbola, RA
通讯作者：
Adegbola, RA
细支气管炎儿童的多种病毒呼吸道病原体。
DOI：
10.1111/j.1651-2227.2008.01023.x
发表时间：
2009-01
期刊：
Acta paediatrica (Oslo, Norway : 1992)
影响因子：
--
作者：
Stempel HE;Martin ET;Kuypers J;Englund JA;Zerr DM
通讯作者：
Zerr DM