Eosinophilic granuloma of skin and mucous membrane; association with diabetes insipidus.
Eosinophilic granuloma of skin and mucous membrane; association with diabetes insipidus.
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皮肤、粘膜嗜酸性肉芽肿；
作者：
Robert B. Kierland;John G. Epstein;Walter E. Weber
与包括嗜酸性肉芽肿、* Hand-Schuller-Christian † 和 Letterer-Siwe ‡ 病在内的一组疾病相关的皮肤病已在其他地方进行了彻底的回顾。§ 急性 Letterer-Siwe 病的皮肤表现通常具有瘀点、瘀斑或紫癜性质。已发现类似脂溢性皮炎的皮疹，甚至有一例报告出现口腔粘膜坏死、溃疡性心绞痛。无论涉及哪个系统，即皮肤、内脏或骨骼，组织学图像本质上都是相同的。大约三分之一的 Hand-Schuller-Christian 病患者有皮肤病变。这些包括丘疹脓疱性皮疹、脂溢性和紫癜性病变、古铜色变色以及眼睛和黄色瘤周围偶尔的类脂浸润，尤其是播散性类型。很少见与骨嗜酸性肉芽肿相关的皮肤改变。然而，已经注意到与骨嗜酸性病变具有相同组织学结构的肉芽肿性病变
The dermatologic disturbances associated with the group of conditions which includes eosinophilic granuloma, * Hand-Schuller-Christian † and Letterer-Siwe ‡ disease have been reviewed thoroughly elsewhere.§ The cutaneous findings in acute Letterer-Siwe disease are generally of a petechial, ecchymotic, or purpuric nature. Eruptions resembling seborrheic dermatitis have been noted, and even a necrotic, ulcerating angina of the oral mucosa has been reported in one case. The histologic picture is essentially the same regardless of the system involved, that is, skin, viscera, or bone. Approximately one-third of the patients with Hand-Schuller-Christian disease have cutaneous lesions. These consist of papulopustular eruptions, seborrheic and purpuric lesions, bronze discoloration, and occasionally lipoid infiltration about the eyes and xanthomas, especially of the disseminate variety. Cutaneous alterations are rarely seen in association with eosinophilic granuloma of bone. However, granulomatous lesions with the same histologic structure as eosinophilic lesions of bone have been noted
组织细胞增多症-X。
DOI：
10.1056/nejm198101153040304
发表时间：
1981
期刊：
The New England journal of medicine
影响因子：
--
作者：
Osband,ME;Lipton,JM;Lavin,P;Levey,R;Vawter,G;Greenberger,JS;McCaffrey,RP;Parkman,R
通讯作者：
Parkman,R