Effects of superoxide dismutase and catalase derivates on intracerebral hemorrhage-induced brain injury in rats.
Effects of superoxide dismutase and catalase derivates on intracerebral hemorrhage-induced brain injury in rats.
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超氧化物歧化酶和过氧化氢酶衍生物对大鼠脑出血所致脑损伤的影响。
DOI：
10.1007/978-3-211-09469-3_7
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Tang,J
中科院分区：
文献类型：
--
作者：
Titova,E;Ostrowski,RP;Rowe,J;Chen,W;Zhang,JH;Tang,J
The use of exogenous superoxide dismutase (SOD) and catalase (CAT) has been previously evaluated against various reactive oxygen species-mediated brain injuries, especially those associated with ischemia/ reperfusion. In this study, we investigated effects of these enzymatic antioxidants on intracerebral hemorrhage (ICH)-induced brain injury.A total of 65 male Sprague-Dawley rats (300-380g) were divided into a sham group, an untreated ICH group, 3 groups of ICH rats treated with lecithinized SOD (PC-SOD) at doses of 0.1,0.3, and 1 mg/kg, and a group treated with polyethylene glycol conjugated CAT (PEG-CAT) at a dose of 10,000 U/kg. An additional group of ICH rats received a combination of PC-SOD (1 mg/kg) and PEG-CAT (10,000 U/kg). ICH was induced by collagenase injection. All drugs were administered intravenously immediately after ICH induction. Brain injury was evaluated by scoring neurological function and measuring brain edema at 24 h after ICH induction.Our results demonstrated that ICH caused significant neurological deficit associated with remarkable brain edema. Treatment with PC-SOD, PEG-CAT, or PC-SOD in combination with PEG-CAT did not reduce brain edema or neurological deficit after ICH. We conclude that intravenously administered PC-SOD and/or PEG-CAT do not reduce brain injury in the collagenase-induced ICH rat model.
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