Expression and prognostic value of cell-cycle-associated genes in gastric adenocarcinoma.
Expression and prognostic value of cell-cycle-associated genes in gastric adenocarcinoma.
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细胞周期相关基因在胃腺癌中的表达及预后价值
DOI：
10.1186/s12876-018-0811-1
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发表时间：
2018-06-08
影响因子：
2.4
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Wang D;Zhu H;Guo M;Fan X;Hu S;Yan K;Sun J;Wang J;Li M;Xiao H;Liu Z
研究背景胃癌是一种恶性疾病，胃腺癌是最常见的组织学类型。GAC的分子图谱已经得到了广泛的应用，但很少有人关注细胞周期基因簇的临床意义。根据cBio门户网站，从TCGA网站下载了该基因的表达和临床数据。我们进行了一系列分析来检测这些基因与GAC之间的关系。结果从所有患者中，根据122个细胞周期相关基因的mRNA表达，确定了5个簇。第1组预后最差，WEE2和CCNE1的表达水平极高。基因图谱的比较表明，16个基因在每个簇之间的表达存在明显的差异。此外，对这16个基因的预后作用的研究表明，ESPL1和MCM5的高表达与良好的预后显著相关。此外，ESPL1和MCM5基因的表达与GAC的病理分期呈负相关。结论本研究揭示了GAC不同亚型细胞周期的基因表达模式，提示单个基因与临床转归和AJCC分期有关。这些结果提示了GAC的一种新的预后策略，并为患者分层和靶向治疗试验提供了信息。
BackgroundGastric carcinoma is a malignant disease, and gastric adenocarcinoma (GAC) is the most common histological type. Molecular profiling of GAC has been extensively performed, but few have focused on the clinical significance of gene clusters of the cell cycle.MethodsWe investigated the genetic profile of cell-cycle-associated genes in a GAC cohort. The mRNA expression and clinical data were downloaded from TCGA, according to cBioportal. We conducted a series of analyses to detect the relationships between these genes and GAC.ResultsFrom all the patients, 5 clusters were identified based on mRNA expression of 122 cell-cycle-associated genes. Cluster 1 showed the worst prognosis and is characterized by extremely high expression ofWEE2andCCNE1. Comparison of the gene patterns showed that 16 genes expressed were distinctly varied between each cluster. In addition, investigations into the prognostic role of the 16 genes suggested that high expression ofESPL1andMCM5were significantly correlated with favorable outcomes. Moreover, we detected thatESPL1andMCM5gene expression were negatively correlated with GAC pathologic stage progression.ConclusionsThis study revealed a gene expression pattern of the cell cycle in different GAC subgroups, and suggested individual genes were associated with the clinical outcome and AJCC stages. These results suggest a novel prognostic strategy for GAC and provide information for patient stratification and trials of targeted therapies.
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影响因子：
8.8
作者：
Park JH;van Wyk H;Roxburgh CSD;Horgan PG;Edwards J;McMillan DC
通讯作者：
McMillan DC
影响因子：
29.4
作者：
Tan IB;Ivanova T;Lim KH;Ong CW;Deng N;Lee J;Tan SH;Wu J;Lee MH;Ooi CH;Rha SY;Wong WK;Boussioutas A;Yeoh KG;So J;Yong WP;Tsuburaya A;Grabsch H;Toh HC;Rozen S;Cheong JH;Noh SH;Wan WK;Ajani JA;Lee JS;Tellez MS;Tan P
通讯作者：
Tan P
影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
30.8
作者：
Wang, Kai;Kan, Junsuo;Leung, Suet Yi
通讯作者：
Leung, Suet Yi
影响因子：
3.7
作者：
Melck, Adrienne;Masoudi, Hamid;Wiseman, Sam M.
通讯作者：
Wiseman, Sam M.