Kinetic aspects of follicular development in the rat.
Kinetic aspects of follicular development in the rat.
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大鼠卵泡发育的动力学方面。
DOI：
10.1007/978-1-4684-5395-9_11
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发表时间：
1987
影响因子：
--
通讯作者：
W. Schmidt
中科院分区：
文献类型：
--
作者：
A. Hirshfield;W. Schmidt
卵巢与成人的其他“再生组织”有许多相似之处。更新组织是指分化的、有功能的细胞不断被更原始的细胞增殖取代的组织。这些组织由一个细胞层次组成：该层次的一端是分化较少的干细胞，可以无限制地分裂；另一端是高度分化的成熟细胞，没有增殖能力(Mackillop等人，1983)。当干细胞分裂时，每个子代细胞都有一个选择：要么继续作为干细胞，要么开始不可逆转地走向终末分化的“克隆扩张”过程(图1)。进入第二阶段的子代细胞被称为“过渡性细胞”(Selby等人，1983)或“定向祖细胞”(Fitchen等人，1981)。过渡细胞的细胞分裂能力有限。它们沿着单向载体呈现出连续的属性梯度；随着细胞沿着层次结构向下移动，它们获得了与特定组织功能相关的分化特征，并逐渐失去了分裂的潜力(Mackillop等人，1983)。组织内分化程度越高的后代细胞数量就越多，分化程度越低的祖细胞数量越多。
The ovary has many similarities to other “renewal tissues” in adults. Renewal tissues are those in which differentiated, functional cells are continuously being replaced by proliferation of more primitive cells. These tissues are composed of a hierarchy of cells: at one end of the hierarchy are stem cells which are less differentiated and can divide without limit; at the other end are mature cells which are highly differentiated and have no capacity for proliferation (Mackillop et al., 1983). When a stem cell divides, each daughter cell has a choice: it can either remain a stem cell, or it can embark on a course of “clonal expansion” leading irreversibly to terminal differentiation (Fig 1). Daughter cells which embark on the second course are known as “transitional cells (Selby et al., 1983) or “committed progenitor cells” (Fitchen et al., 1981). Transitional cells have a limited capacity for cell division. They exhibit a continuous gradient of properties along a unidirectional vector; as cells move down the hierarchy, they acquire the differentiated features associated with specific tissue function, and they progressively lose the potential to divide (Mackillop et al., 1983). The more highly differentiated progeny greatly outnumber the less differentiated progenitor cells within the tissue.
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体外颗粒细胞分化：胰岛素对生长和功能完整性的影响。
影响因子：
3.6
作者：
May,JV;Schomberg,DW
通讯作者：
Schomberg,DW
大鼠颗粒细胞分化：体外模型。
影响因子：
4.8
作者：
Sanders,MM;MidgleyJr,AR
通讯作者：
MidgleyJr,AR
DOI：
10.1016/b978-0-12-571139-5.50018-5
发表时间：
1983
期刊：
Recent progress in hormone research
影响因子：
--
作者：
Gerald R. Cunha;L. W. Chung;John M. Shannon;O. Taguchi;H. Fujii
通讯作者：
Gerald R. Cunha;L. W. Chung;John M. Shannon;O. Taguchi;H. Fujii
影响因子：
4.8
作者：
AGUADO, LI;OJEDA, SR
通讯作者：
OJEDA, SR
新生儿促性腺激素的释放对于卵泡刺激激素受体的发育至关重要。
影响因子：
3.6
作者：
Smith,SS;Ojeda,SR
通讯作者：
Ojeda,SR