Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation.
Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation.
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DOI：
10.1016/j.chom.2017.07.005
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发表时间：
2017-08-09
影响因子：
30.3
通讯作者：
Isberg RR
中科院分区：
文献类型：
--
作者：
Mitchell G;Isberg RR
最近关于细胞内微生物的免疫清除的兴奋集中在维持细胞内稳态的两个系统上。一种系统包括细胞自噬成分，其在称为异食的过程中介导膜结合区室中病原体的降解。第二个系统由干扰素调节的GTP酶驱动，其促进含有病原体的空泡的破裂和微生物降解。在异食的情况下，病原体隔离和区室化抑制炎症。相比之下，干扰素驱动的事件可导致病原体相关分子模式暴露于宿主胞质溶胶，随之发生炎性小体激活。奇怪的是，信号和因子参与异食也动员干扰素调节的GTP酶，驱动炎症反应，表明这些途径之间相当大的串扰。如何确定这些应对措施的优先次序仍有待了解。在这篇综述中，我们描述了细胞内病原体清除的机制，依赖于自噬机制和干扰素调节的GTP酶，并推测这些途径如何相互作用，以平衡病原体消除与炎症。
Recent excitement regarding immune clearance of intracellular microorganisms has focused on two systems that maintain cellular homeostasis. One system includes cellular autophagy components that mediate degradation of pathogens in membrane-bound compartments, in a process termed xenophagy. The second system is driven by interferon– regulated GTPases that promote rupture of pathogen-containing vacuoles and microbial degradation. In the case of xenophagy, pathogen sequestration and compartmentalization suppress inflammation. In contrast, interferon-driven events can lead to exposure of pathogen-associated molecular patterns to the host cytosol with consequent inflammasome activation. Paradoxically, signals and factors involved in xenophagy also mobilize interferon-regulated GTPases, which drive the inflammatory response, indicating considerable crosstalk between these pathways. How these responses are prioritized remains to be understood. In this review, we describe mechanisms of intracellular pathogen clearance that rely on the autophagy machinery and interferon-regulated GTPases, and speculate how these pathways engage each other to balance pathogen elimination with inflammation.
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E2样共轭酶ATG3促进了IRG和GBP蛋白与衣原体和含毒素的液泡的结合以及宿主的耐药性。
影响因子：
3.7
作者：
Haldar AK;Piro AS;Pilla DM;Yamamoto M;Coers J
通讯作者：
Coers J
沙眼衣原体具有抗包容性泛素化和相关的宿主防御能力的伽玛干扰素上皮细胞。
影响因子：
6.4
作者：
Haldar AK;Piro AS;Finethy R;Espenschied ST;Brown HE;Giebel AM;Frickel EM;Nelson DE;Coers J
通讯作者：
Coers J
DOI：
10.1083/jcb.201304188
发表时间：
2013-10-14
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fujita N;Morita E;Itoh T;Tanaka A;Nakaoka M;Osada Y;Umemoto T;Saitoh T;Nakatogawa H;Kobayashi S;Haraguchi T;Guan JL;Iwai K;Tokunaga F;Saito K;Ishibashi K;Akira S;Fukuda M;Noda T;Yoshimori T
通讯作者：
Yoshimori T
影响因子：
4.6
作者：
Hubber A;Kubori T;Coban C;Matsuzawa T;Ogawa M;Kawabata T;Yoshimori T;Nagai H
通讯作者：
Nagai H
DOI：
10.1073/pnas.1615771114
发表时间：
2017-02-28
影响因子：
11.1
作者：
Feeley, Eric M.;Pilla-Moffett, Danielle M.;Coers, Joern
通讯作者：
Coers, Joern