It's complicated: the interplay of Kif1c mRNA localization in cell protrusions, assembly of protein binding partners on the KIF1C protein, and cell migration.
It's complicated: the interplay of Kif1c mRNA localization in cell protrusions, assembly of protein binding partners on the KIF1C protein, and cell migration.
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DOI：
10.1101/gad.350538.123
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发表时间：
2023-03-01
影响因子：
10.5
通讯作者：
Braselmann, Esther
中科院分区：
文献类型：
--
作者：
Sarfraz, Nadia;Braselmann, Esther
关键词：
在这种前景中，萨弗拉斯和布拉塞尔曼在诺里斯和门德尔在本期《基因与发展》中讨论了一篇论文，该论文系统地研究了小鼠黑色素细胞系统中mRNA定位与细胞突起之间的联系，以及与细胞迁移率下游后果的机械联系。
在各种细胞中，已经描述了MRNA的明显的亚细胞，而神经元细胞中的常见主题则在非神经元细胞中较少了解mRNA的功能。 link between mRNA localization to cell proteins in a mouse melanoma cell system and a mechanical link to downstream consequences for cell mobility. The study first identifies a model mRNA of interest in an unbiased way that exhibits a set of phenotypes associated with cell mobility. The candidate mRNA that fulfills all requirements is Kif1c mRNA. Further systematic investment links Kif1c mRNA localization to assembly of a protein–protein network on the KIF1C protein清楚的是，这项工作会激发KIF1C mRNA/KIF1C蛋白质相互作用的进一步的机械解剖，在这种重要的非神经元模型细胞系统中，这项工作应研究广泛的模型mRNA，以了解MRNA的动态和下游功能。
In this Outlook, Sarfraz and Braselmann discuss a paper in this issue of Genes & Development by Norris and Mendell that systematically investigates a link between mRNA localization to cell protrusions in a mouse melanomal cell system and the mechanistic link to downstream consequences for cell mobility. Distinct subcellular localizations of mRNAs have been described across a wide variety of cell types. While common themes emerge for neuronal cells, functional roles of mRNA localization in space and time are much less understood in nonneuronal cells. Emerging areas of interest are cell models with protrusions, often linked with cell mobility in cancer systems. In this issue of Genes & Development, Norris and Mendell (pp. 191–203) systematically investigate a link between mRNA localization to cell protrusions in a mouse melanoma cell system and a mechanistic link to downstream consequences for cell mobility. The study first identifies a model mRNA of interest in an unbiased way that exhibits a set of phenotypes associated with cell mobility. The candidate mRNA that fulfills all requirements is Kif1c mRNA. Further systematic investigation links Kif1c mRNA localization to assembly of a protein–protein network on the KIF1C protein itself. What's clear is that this work will inspire a further mechanistic dissection of the Kif1c mRNA/KIF1C protein interplay in this important nonneuronal model cell system. More broadly, this work suggests that a broad set of model mRNAs should be investigated to understand mRNA dynamics and downstream functional consequences across a variety of cell models.
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DOI：
10.1126/science.1242939
发表时间：
2014-01-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Buxbaum AR;Wu B;Singer RH
通讯作者：
Singer RH
影响因子：
11.8
作者：
Mardakheh, Faraz K.;Paul, Angela;Marshall, Christopher J.
通讯作者：
Marshall, Christopher J.
影响因子：
10.5
作者：
Norris, Megan L.;Mendell, Joshua T.
通讯作者：
Mendell, Joshua T.
DOI：
10.1261/rna.078576.120
发表时间：
2021-12
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Pichon X;Moissoglu K;Coleno E;Wang T;Imbert A;Robert MC;Peter M;Chouaib R;Walter T;Mueller F;Zibara K;Bertrand E;Mili S
通讯作者：
Mili S
DOI：
10.15252/embj.2020106003
发表时间：
2020-11-02
期刊：
The EMBO journal
影响因子：
--
作者：
Costa G;Bradbury JJ;Tarannum N;Herbert SP
通讯作者：
Herbert SP