PET scanning and the human immunodeficiency virus-positive patient.
PET scanning and the human immunodeficiency virus-positive patient.
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PET 扫描和人类免疫缺陷病毒阳性患者。
DOI：
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发表时间：
1997
影响因子：
9.3
通讯作者：
C. Bradbeer
中科院分区：
文献类型：
--
作者：
M. O'Doherty;S. Barrington;Meg Campbell;J. Lowe;C. Bradbeer
未标记
研究了PET扫描在人类免疫缺陷病毒感染和不明原因发热、意识模糊和/或体重减轻患者中的应用。
方法
80例患者接受了PET检查。57例患者进行了[18 F]氟脱氧葡萄糖（FDG）半身扫描，23例患者进行了FDG脑部研究。14例患者还进行了[11 C]蛋氨酸研究（2例胸部、1例腹部和11例脑部）。
结果
13例淋巴瘤患者的淋巴结和淋巴结部位的疾病程度都清楚。患有各种感染（新型隐球菌、铜绿假单胞菌、结核分枝杆菌和胞内鸟分枝杆菌）的患者具有疾病定位，以进行适当的活检或取样程序。半身FDG-PET扫描对需要治疗的病灶病变定位的敏感性为92%，特异性为94%。高摄取FDG（大于肝脏）对需要治疗的病理有95%的阳性预测值。FDG脑研究显示，16例CD 4 T淋巴细胞计数低于200个细胞/ml的患者与基底节相比，皮质摄取减少。19例经磁共振检查证实的局灶性占位性病变，FDG扫描均异常。弓形虫引起的脑病变的标准化摄取值（SUV）范围为0.14-3.7（13例患者），淋巴瘤引起的范围为3.9-8.7（6例患者）。另外3例进行性多灶性白质脑病患者的SUV在病变范围内为1.0-1.5。另一名患者患有低级别少突胶质细胞瘤（SUV = 2.9）。脑淋巴瘤患者的碳-11-甲硫氨酸摄取也很高，但在这些患者的FDG扫描中并没有增加弓形虫病和淋巴瘤之间的区分。
结论
在有PET设备的医院，FDG扫描可以快速评估人体免疫缺陷病毒感染患者的全身，包括大脑，并可能在注射后4小时内提供报告。感染和肿瘤的部位进行了鉴定，脑病理之间的歧视是可能的。
UNLABELLED
The use of PET scanning in patients with human immunodeficiency virus infection and fever of unknown origin, confusion and/or weight loss was investigated.
METHODS
Eighty patients were examined using PET. Fifty-seven patients had half-body scans with [18F]fluorodeoxyglucose (FDG), and 23 patients had brain studies performed with FDG. Fourteen patients also had [11C]methionine studies (2 chest, 1 abdomen and 11 brain) performed.
RESULTS
Thirteen patients with lymphoma had the extent of the disease clearly identified in both nodal and extranodal sites. Patients with a variety of infections (Cryptococcus neoformans, Pseudomonas aeruginosa, Mycobacterium tuberculosis and Mycobacterium avium intracellulare) had disease localized for appropriate biopsy or sampling procedures. A half-body FDG-PET scan had a sensitivity of 92% and a specificity of 94% for localization of focal pathology that needed treatment. High uptake of FDG (greater than liver) had a positive predictive value for pathology needing treatment of 95%. FDG brain studies showed that 16 patients with CD4 T-lymphocyte counts less than 200 cells/ml had reduced cortical uptake compared with that in basal ganglia. FDG scans were abnormal in all 19 patients with focal space occupying lesions identified by magnetic resonance scans. The standardized uptake values (SUVs) over cerebral lesions due to toxoplasma were in the range of 0.14-3.7 (13 patients) and due to lymphoma were in the range of 3.9-8.7 (6 patients). Three more patients with progressive multifocal leukoencephalopathy had SUVs in the range of 1.0-1.5 over the lesions. Another patient had a low-grade oligodendroglioma (SUV = 2.9). Carbon-11-methionine uptake also was high in patients with cerebral lymphoma but did not add to the discrimination between toxoplasmosis and lymphoma in these patients obtained with the FDG scan.
CONCLUSION
In hospitals with access to PET facilities, FDG scanning allows the rapid evaluation of the whole body, including the brain, of patients with human immunodeficiency virus infection, with a report potentially available within 4 hr of injection. Sites of infection and tumor were identified, and discrimination between cerebral pathologies was possible.
获得性免疫缺陷综合症（艾滋病）的神经外科影响。
DOI：
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发表时间：
1988
期刊：
Clinical neurosurgery
影响因子：
--
作者：
Rosenblum,ML;Levy,RM;Bredesen,DE
通讯作者：
Bredesen,DE
DOI：
--
发表时间：
1991-04
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
L. Strauss;P. Conti
通讯作者：
L. Strauss;P. Conti