Prevalence of HTLV type I infection in Iran: a serological and genetic study.
Prevalence of HTLV type I infection in Iran: a serological and genetic study.
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伊朗 HTLV I 型感染流行率：一项血清学和遗传学研究。
DOI：
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发表时间：
1996
影响因子：
1.5
通讯作者：
Genoveffa Franchini
中科院分区：
文献类型：
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作者：
B. Safai;Jun;Enzo Boeri;Reza Farid;Jahangir Raafat;Pamela Schutzer;Rosaline Ahkami;Genoveffa Franchini
一些出版物描述了在伊朗马什哈德出生的犹太人中存在人类T细胞嗜淋巴细胞病毒I型（HTLV-I）。我们在这里报告的结果HTLV-I血清学和遗传学研究的非犹太人口的马什哈德以及邻近地区：贡巴德-卡武斯。通过明胶颗粒凝集试验（PA）和确证性蛋白质印迹法（WB）检测了707份来自Mash-had（694名健康个体和13名淋巴瘤患者）和90份来自Gonbad-Kavous的血清样本的HTLV抗体。在Mash-had、Gonbad-Kavous和淋巴瘤病例中观察到的血清阳性率分别为3.0%（21/694）、0%（0/90）和100%（13/13）。直接从血清学阳性个体的新鲜PBMCs中通过聚合酶链反应扩增HTLV-I DNA序列。病毒DNA序列的系统发育分析表明，HTLV-I存在于Mash-Had属于HTLV-I世界性分支。总的来说，这些数据表明，位于伊朗东北部的马什哈德是一个新认识到的HTLV-I地方病中心。
Several publications describe the presence of the human T cell lymphotropic virus type I (HTLV-I) in Jewish individuals born in Mash-had, Iran. We report here the results of HTLV-I serological and genetic studies in the non-Jewish population of Mash-had as well as a neighboring area: Gonbad-Kavous. Seven hundred and seven serum samples from Mash-had (694 healthy individuals and 13 patients with lymphoma) and 90 from Gonbad-Kavous were tested for HTLV antibodies by gelatin particle agglutination assay (PA) and confirmatory Western blots (WBs). Seropositive rates of 3.0% (21 of 694) in Mash-had, 0% (0 of 90) in Gonbad-Kavous, and 100% (13 of 13) in lymphoma cases were observed. HTLV-I DNA sequence were amplified by polymerase chain reaction directly from the fresh PBMCs of seropositive individuals. Phylogenetic analysis of the viral DNA sequence indicated that the HTLV-I present in Mash-had belong to the HTLV-I cosmopolitan clade. Altogether, these data indicate that Mash-had, located in northeastern Iran, is a newly recognized endemic center for HTLV-I.
多发性肌炎患者 T 细胞白血病/淋巴瘤病毒 I 型抗体、DNA 和蛋白质的鉴定。
影响因子：
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作者：
Sherman,MP;Amin,RM;Rodgers-Johnson,PE;Morgan,OS;Char,G;Mora,CA;Iannone,R;Collins,GH;Papsidero,L;GibbsJr,CJ
通讯作者：
GibbsJr,CJ