Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies.
Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies.
复制标题
DOI：
10.1093/hmg/ddy036
复制
发表时间：
2018-04-01
影响因子：
3.5
通讯作者：
Howe LD
中科院分区：
文献类型：
--
作者：
Lawn RB;Anderson EL;Suderman M;Simpkin AJ;Gaunt TR;Teschendorff AE;Widschwendter M;Hardy R;Kuh D;Relton CL;Howe LD
儿童时期的心理社会逆境（例如虐待）和社会经济地位低下（SEP）可能对社会和健康结果产生重大的持久影响。基于DNA甲基化的生物标志物与实际年龄高度相关;甲基化预测年龄与实际年龄的偏离可用于定义年龄加速的量度，这可能代表将环境暴露与以后的健康结果联系起来的潜在生物学机制。使用来自两组女性的数据，雅芳父母和子女纵向研究（ALSPAC，N = 989）和MRC国家健康与发展调查（NSHD，N = 773），我们评估了SEP，儿童期心理社会逆境（父母身体或精神疾病或死亡，父母分居，父母缺席，次优的母亲关系，性，情感和身体虐待和忽视）和这些心理社会逆境测量的累积评分，以及成年期DNA甲基化年龄加速（在ALSPAC中在平均实足年龄29和47时在外周血中测量，在NSHD中在53岁时在颊细胞中测量）。在ALSPAC中，性虐待与年龄加速密切相关（在NSHD中没有性虐待数据），例如，在47岁的时间点，性虐待与高3.41岁的DNA甲基化年龄相关（95%CI 1.53 - 5.29）。未观察到低SEP，任何其他心理社会逆境指标或累积心理社会逆境评分和年龄加速。DNA甲基化年龄加速与性虐待有关，这表明性虐待与不良结果之间存在潜在机制。需要进行更大样本量的重复研究。
Psychosocial adversity in childhood (e.g. abuse) and low socioeconomic position (SEP) can have significant lasting effects on social and health outcomes. DNA methylation-based biomarkers are highly correlated with chronological age; departures of methylation-predicted age from chronological age can be used to define a measure of age acceleration, which may represent a potential biological mechanism linking environmental exposures to later health outcomes. Using data from two cohorts of women Avon Longitudinal Study of Parents and Children, (ALSPAC), N = 989 and MRC National Survey of Health and Development, NSHD, N = 773), we assessed associations of SEP, psychosocial adversity in childhood (parental physical or mental illness or death, parental separation, parental absence, sub-optimal maternal bonding, sexual, emotional and physical abuse and neglect) and a cumulative score of these psychosocial adversity measures, with DNA methylation age acceleration in adulthood (measured in peripheral blood at mean chronological ages 29 and 47 in ALSPAC and buccal cells at age 53 in NSHD). Sexual abuse was strongly associated with age acceleration in ALSPAC (sexual abuse data were not available in NSHD), e.g. at the 47-year time point sexual abuse associated with a 3.41 years higher DNA methylation age (95% CI 1.53 to 5.29) after adjusting for childhood and adulthood SEP. No associations were observed between low SEP, any other psychosocial adversity measure or the cumulative psychosocial adversity score and age acceleration. DNA methylation age acceleration is associated with sexual abuse, suggesting a potential mechanism linking sexual abuse with adverse outcomes. Replication studies with larger sample sizes are warranted.
登录
查看更多内容
影响因子：
15.8
作者：
Relton CL;Davey Smith G
通讯作者：
Davey Smith G
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
120.7
作者：
ADLER, NE;BOYCE, WT;SYME, SL
通讯作者：
SYME, SL
影响因子：
7.7
作者：
Relton CL;Gaunt T;McArdle W;Ho K;Duggirala A;Shihab H;Woodward G;Lyttleton O;Evans DM;Reik W;Paul YL;Ficz G;Ozanne SE;Wipat A;Flanagan K;Lister A;Heijmans BT;Ring SM;Davey Smith G
通讯作者：
Davey Smith G
影响因子：
3.3
作者：
Cicchetti D;Hetzel S;Rogosch FA;Handley ED;Toth SL
通讯作者：
Toth SL